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Jakobsson JE, Grønnevik G, Riss PJ. Organocatalyst-assisted Ar-. Chem Commun (Camb). 2017;53(96):12906-12909doi: 10.1039/c7cc07211b.
Jakobsson, J. E., Grønnevik, G., & Riss, P. J. (2017). Organocatalyst-assisted Ar-. Chemical communications (Cambridge, England), 53(96), 12906-12909. https://doi.org/10.1039/c7cc07211b
Jakobsson, Jimmy Erik, et al. "Organocatalyst-assisted Ar-." Chemical communications (Cambridge, England) vol. 53,96 (2017): 12906-12909. doi: https://doi.org/10.1039/c7cc07211b
Jakobsson JE, Grønnevik G, Riss PJ. Organocatalyst-assisted Ar-. Chem Commun (Camb). 2017 Nov 30;53(96):12906-12909. doi: 10.1039/c7cc07211b. PMID: 29143838.
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Chem Commun (Camb). 2017 Nov 30;53(96):12906-12909. doi: 10.1039/c7cc07211b.

Organocatalyst-assisted Ar-.

Chemical communications (Cambridge, England)

Jimmy Erik Jakobsson, Gaute Grønnevik, Patrick Johannes Riss

Affiliations

  1. Realomics Strategic Research Initiative, Department of Chemistry, Faculty for Mathematics and Natural Sciences, University of Oslo, Norway. [email protected].

PMID: 29143838 DOI: 10.1039/c7cc07211b

Abstract

A metal free, phosphane-catalysed protocol for C-F bond formation based on ipso-elimination of iodanes is described. The reaction proceeds in significantly higher yield and with markedly reduced variability of yields (yield range) than previously described procedures. Rapid and efficient radiofluorination is achieved using unobjectionable chemical reagents with precedence in routine radiotracer production. With operational ease and mild conditions, the method promises a high potential for radiolabelling of biomolecules.

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