Display options
Cite
Chen X, Wang FY, Chu GJ, et al. Balloon-expanding stent and delivery system for transcatheter aortic valve implantation: An animal study. Chronic Dis Transl Med. 2015;1(2):73-80doi: 10.1016/j.cdtm.2015.06.005.
Chen, X., Wang, F. Y., Chu, G. J., Zhu, Y. F., Tan, H. W., Zhao, X. X., Qin, Y. W., & Ge, J. B. (2015). Balloon-expanding stent and delivery system for transcatheter aortic valve implantation: An animal study. Chronic diseases and translational medicine, 1(2), 73-80. https://doi.org/10.1016/j.cdtm.2015.06.005
Chen, Xiang, et al. "Balloon-expanding stent and delivery system for transcatheter aortic valve implantation: An animal study." Chronic diseases and translational medicine vol. 1,2 (2015): 73-80. doi: https://doi.org/10.1016/j.cdtm.2015.06.005
Chen X, Wang FY, Chu GJ, Zhu YF, Tan HW, Zhao XX, Qin YW, Ge JB. Balloon-expanding stent and delivery system for transcatheter aortic valve implantation: An animal study. Chronic Dis Transl Med. 2015 Jul 04;1(2):73-80. doi: 10.1016/j.cdtm.2015.06.005. eCollection 2015 Jun. PMID: 29062990; PMCID: PMC5643579.
Copy Download .nbib Format: NLM
Share it on

Chronic Dis Transl Med. 2015 Jul 04;1(2):73-80. doi: 10.1016/j.cdtm.2015.06.005. eCollection 2015 Jun.

Balloon-expanding stent and delivery system for transcatheter aortic valve implantation: An animal study.

Chronic diseases and translational medicine

Xiang Chen, Fei-Yu Wang, Guo-Jun Chu, Yu-Feng Zhu, Hong-Wen Tan, Xian-Xian Zhao, Yong-Wen Qin, Jun-Bo Ge

Affiliations

  1. Department of Cardiology, ZhongShan Hospital, Fudan University, Shanghai 200032, China.
  2. Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.

PMID: 29062990 PMCID: PMC5643579 DOI: 10.1016/j.cdtm.2015.06.005

Abstract

OBJECTIVE: To evaluate the feasibility and satefy of transcatheter aortic valve implantation in animals by using a new balloon-expanding valved stent.

METHODS: The balloon-expandable stent is made from cobalt-based alloy material and designed with a tubular, slotted structure. Fresh bovine pericardium was treated, sutured and fixed on the balloon-expandable stent. Ten healthy sheep (five males and five females), weighing an average of (25.16 ± 1.83) kg, were selected to undergo transcatheter implantation of the valve stents. The function of the valve stent was evaluated by angiography, echocardiography, and histology six months after the procedure.

RESULTS: Of the ten experimental sheep, two sheep died during the operation because the higher position of the artificial valve affected the opening of the coronary artery. We successfully implanted the aortic valve stent in other eight sheep; however, one sheep died of heart failure two weeks after the operation due to the lower position of the valve stent. The valve stents were implanted in the desired position in seven sheep. Ascending aortic angiographic and autoptic findings immediately after the operation confirmed the satisfactory location and function of the valved stent. Echocardiography, angiography, and histology at six postoperative months confirmed the satisfactory location and function of the valve stent.

CONCLUSION: We successfully implanted our new valve stent as a replacement of native aortic valve via the transcatheter route with satisfactory outcome.

Keywords: Aortic valve replacement; Balloon-expandable stent; Percutaneous; Stent shifting

References

  1. N Engl J Med. 2011 Jun 9;364(23):2187-98 - PubMed
  2. Circulation. 2002 Dec 10;106(24):3006-8 - PubMed
  3. EuroIntervention. 2012 Sep;8 Suppl Q:Q18-20 - PubMed
  4. J Am Coll Cardiol. 2012 Mar 27;59(13):1200-54 - PubMed
  5. Circulation. 2006 Feb 14;113(6):842-50 - PubMed
  6. Lancet. 2006 Sep 16;368(9540):1005-11 - PubMed
  7. J Am Coll Cardiol. 2014 Jun 10;63(22):2438-88 - PubMed

Publication Types