Display options
Cite
Schlesinger-Raab A, Werner J, Friess H, et al. Age and Outcome in Gastrointestinal Cancers: A Population-Based Evaluation of Oesophageal, Gastric and Colorectal Cancer. Visc Med. 2017;33(4):245-253doi: 10.1159/000477104.
Schlesinger-Raab, A., Werner, J., Friess, H., Hölzel, D., & Engel, J. (2017). Age and Outcome in Gastrointestinal Cancers: A Population-Based Evaluation of Oesophageal, Gastric and Colorectal Cancer. Visceral medicine, 33(4), 245-253. https://doi.org/10.1159/000477104
Schlesinger-Raab, Anne, et al. "Age and Outcome in Gastrointestinal Cancers: A Population-Based Evaluation of Oesophageal, Gastric and Colorectal Cancer." Visceral medicine vol. 33,4 (2017): 245-253. doi: https://doi.org/10.1159/000477104
Schlesinger-Raab A, Werner J, Friess H, Hölzel D, Engel J. Age and Outcome in Gastrointestinal Cancers: A Population-Based Evaluation of Oesophageal, Gastric and Colorectal Cancer. Visc Med. 2017 Aug;33(4):245-253. doi: 10.1159/000477104. Epub 2017 Aug 07. PMID: 29034252; PMCID: PMC5624268.
Copy Download .nbib Format: NLM
Share it on

Visc Med. 2017 Aug;33(4):245-253. doi: 10.1159/000477104. Epub 2017 Aug 07.

Age and Outcome in Gastrointestinal Cancers: A Population-Based Evaluation of Oesophageal, Gastric and Colorectal Cancer.

Visceral medicine

Anne Schlesinger-Raab, Jens Werner, Helmut Friess, Dieter Hölzel, Jutta Engel

Affiliations

  1. Munich Cancer Registry (MCR) of the Munich Cancer Centre (MCC), Institute for Medical Information Processing, Biometry and Epidemiology (IBE), Klinikum der Universität München (KUM), Ludwig-Maximilians-University (LMU), Munich, Germany.
  2. Department of Surgery, Klinikum der Universität München (KUM), Ludwig-Maximilians-University (LMU), Munich, Germany.
  3. Department of Surgery, Klinikum Rechts der Isar (RDI), Technical University Munich (TUM), Munich, Germany.

PMID: 29034252 PMCID: PMC5624268 DOI: 10.1159/000477104

Abstract

BACKGROUND: With demographic changes and partial representativeness of randomized studies the question arises which results are achieved in the treatment of the elderly. The objective was to analyse population-based data on gastrointestinal cancers in terms of age.

METHODS: Analyses included data of the Munich Cancer Registry, i.e. 4,014, 10,127 and 42,809 invasive oesophageal, gastric and colorectal cancer patients, respectively, which were diagnosed between 1998 and 2014. Tumour characteristics and outcome were analysed by age groups and therapy. Overall survival was analysed using the Kaplan-Meier method, and relative survival was computed as estimation for cancer-specific survival. Additionally, conditional survival of patients surviving at least 6 or 12 months was analysed by age.

RESULTS: 21, 44 and 38% of oesophageal, gastric and colorectal cancer patients, respectively, were aged >75 years. Of these, 15, 46 and 73% were surgically treated with curative intent, respectively, which is significantly less than in younger patients. The total 5-year relative survival was 24, 33 and 66%, respectively. The differences in median survival by age group were diminished by selecting those surviving at least 6 or 12 months and those with curatively intended treatment.

CONCLUSION: An adequate patient selection for therapies of these gastrointestinal cancers was demonstrated at large. If the patients' general conditions allowed curatively intended treatment, it was applied and led to similar outcomes irrespective of age.

Keywords: Cancer registry; Colorectal cancer; Elderly; Gastric cancer; Oesophageal cancer

References

  1. Br J Surg. 2012 Dec;99(12):1693-700 - PubMed
  2. World J Gastrointest Surg. 2016 Sep 27;8(9):606-613 - PubMed
  3. Int Surg. 2012 Jul-Sep;97(3):219-23 - PubMed
  4. Eur J Cancer. 2013 Apr;49(6):1374-403 - PubMed
  5. N Engl J Med. 2001 Aug 30;345(9):638-46 - PubMed
  6. J Geriatr Oncol. 2016 Nov;7(6):479-491 - PubMed
  7. Int J Clin Oncol. 2013 Dec;18(6):1014-9 - PubMed
  8. J Am Coll Surg. 2012 Dec;215(6):858-67 - PubMed
  9. Int J Clin Oncol. 2013 Dec;18(6):969-70 - PubMed
  10. Pathol Oncol Res. 2017 Jan;23 (1):13-17 - PubMed
  11. J Clin Oncol. 2012 Dec 1;30(34):4215-22 - PubMed
  12. World J Surg. 2006 Aug;30(8):1468-74 - PubMed
  13. Oncology (Williston Park). 2010 Jan;24(1):76-85 - PubMed
  14. Cochrane Database Syst Rev. 2000;(2):CD001545 - PubMed
  15. J R Soc Med. 1988 Sep;81(9):503-8 - PubMed
  16. Colorectal Dis. 2017 Jun;19(6):O219-O231 - PubMed
  17. J Clin Oncol. 1983 Nov;1(11):710-9 - PubMed
  18. J Cancer Res Clin Oncol. 2014 May;140(5):789-800 - PubMed
  19. Ann Surg Oncol. 2011 Jan;18(1):26-33 - PubMed
  20. N Engl J Med. 1994 Aug 25;331(8):502-7 - PubMed
  21. World J Gastrointest Surg. 2016 Jan 27;8(1):27-40 - PubMed

Publication Types