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Malíčková K, Francová I, Lukáš M, et al. Fecal zonulin is elevated in Crohn's disease and in cigarette smokers. Pract Lab Med. 2017;9:39-44doi: 10.1016/j.plabm.2017.09.001.
Malíčková, K., Francová, I., Lukáš, M., Kolář, M., Králíková, E., Bortlík, M., Ďuricová, D., Štěpánková, L., Zvolská, K., Pánková, A., & Zima, T. (2017). Fecal zonulin is elevated in Crohn's disease and in cigarette smokers. Practical laboratory medicine, 939-44. https://doi.org/10.1016/j.plabm.2017.09.001
Malíčková, Karin, et al. "Fecal zonulin is elevated in Crohn's disease and in cigarette smokers." Practical laboratory medicine vol. 9 (2017): 39-44. doi: https://doi.org/10.1016/j.plabm.2017.09.001
Malíčková K, Francová I, Lukáš M, Kolář M, Králíková E, Bortlík M, Ďuricová D, Štěpánková L, Zvolská K, Pánková A, Zima T. Fecal zonulin is elevated in Crohn's disease and in cigarette smokers. Pract Lab Med. 2017 Sep 23;9:39-44. doi: 10.1016/j.plabm.2017.09.001. eCollection 2017 Dec. PMID: 29034305; PMCID: PMC5633835.
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Pract Lab Med. 2017 Sep 23;9:39-44. doi: 10.1016/j.plabm.2017.09.001. eCollection 2017 Dec.

Fecal zonulin is elevated in Crohn's disease and in cigarette smokers.

Practical laboratory medicine

Karin Malíčková, Irena Francová, Milan Lukáš, Martin Kolář, Eva Králíková, Martin Bortlík, Dana Ďuricová, Lenka Štěpánková, Kamila Zvolská, Alexandra Pánková, Tomáš Zima

Affiliations

  1. Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital & 1st Faculty of Medicine of the Charles University, U Nemocnice 2, Prague 2 12800, Czech Republic.
  2. IBD Clinical and Research Centre ISCARE, Jankovcova 1569, Prague 7 17000, Czech Republic.
  3. The Centre for Tobacco-Dependent of the 3rd Medical Department - Department of Endocrinology and Metabolism, General University Hospital & 1st Faculty of Medicine of the Charles University, U Nemocnice 1, Prague 2 12800, Czech Republic.

PMID: 29034305 PMCID: PMC5633835 DOI: 10.1016/j.plabm.2017.09.001

Abstract

OBJECTIVES: Human zonulin is a protein that increases permeability in the epithelial layer of the small intestine by reversibly modulating the intercellular tight junctions. There is not sufficient information available about zonulin's participation in inflammatory bowel diseases (IBD). The aim of this study was therefore to investigate fecal and serum zonulin in IBD patients and its relation to the disease localization, behavior and smoking status.

DESIGN AND METHODS: Forty IBD patients and forty healthy persons were examined for fecal and serum zonulin concentrations by competitive ELISA (DRG International Inc). Values were correlated to IBD type, localization and behavior, and smoking.

RESULTS: Serum and fecal zonulin were significantly higher in patients with Crohn's disease compared to ulcerative colitis (p = 0.038 for fecal zonulin, and p = 0.041 for serum zonulin concentrations). No association of serum or fecal zonulin was found with respect to IBD localization and behavior. The only difference was found with respect to smoking. Both the IBD cohort and healthy smokers showed significantly higher fecal zonulin levels (median 203 ng/mL) compared to non-smokers (median 35.8 ng/mL), p < 0.001.

CONCLUSIONS: Fecal and serum zonulin levels are elevated in patients with active Crohn's disease but not with ulcerative colitis. High fecal zonulin levels in smokers irrespective of IBD point to the significant and undesirable up-regulation of gut permeability in cigarette smokers.

Keywords: Crohn's disease; Inflammatory bowel disease; Smoking; Ulcerative colitis; Zonulin

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