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Khan L, Cramarossa G, Chen E, et al. Symptom Clusters Using the Edmonton Symptom Assessment System in Patients With Bone Metastases: A Reanalysis Comparing Different Statistical Methods. World J Oncol. 2012;3(1):23-32doi: 10.4021/wjon403w.
Khan, L., Cramarossa, G., Chen, E., Nguyen, J., Zhang, L., Tsao, M., Danjoux, C., Barnes, E., Sahgal, A., Holden, L., Jon, F., Culleton, S., & Chow, E. (2012). Symptom Clusters Using the Edmonton Symptom Assessment System in Patients With Bone Metastases: A Reanalysis Comparing Different Statistical Methods. World journal of oncology, 3(1), 23-32. https://doi.org/10.4021/wjon403w
Khan, Luluel, et al. "Symptom Clusters Using the Edmonton Symptom Assessment System in Patients With Bone Metastases: A Reanalysis Comparing Different Statistical Methods." World journal of oncology vol. 3,1 (2012): 23-32. doi: https://doi.org/10.4021/wjon403w
Khan L, Cramarossa G, Chen E, Nguyen J, Zhang L, Tsao M, Danjoux C, Barnes E, Sahgal A, Holden L, Jon F, Culleton S, Chow E. Symptom Clusters Using the Edmonton Symptom Assessment System in Patients With Bone Metastases: A Reanalysis Comparing Different Statistical Methods. World J Oncol. 2012 Feb;3(1):23-32. doi: 10.4021/wjon403w. Epub 2012 Feb 19. PMID: 29147274; PMCID: PMC5649832.
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World J Oncol. 2012 Feb;3(1):23-32. doi: 10.4021/wjon403w. Epub 2012 Feb 19.

Symptom Clusters Using the Edmonton Symptom Assessment System in Patients With Bone Metastases: A Reanalysis Comparing Different Statistical Methods.

World journal of oncology

Luluel Khan, Gemma Cramarossa, Emily Chen, Janet Nguyen, Liying Zhang, May Tsao, Cyril Danjoux, Elizabeth Barnes, Arjun Sahgal, Lori Holden, Flo Jon, Shaelyn Culleton, Edward Chow

Affiliations

  1. Rapid Response Radiotherapy Program, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Canada.

PMID: 29147274 PMCID: PMC5649832 DOI: 10.4021/wjon403w

Abstract

BACKGROUND: To determine whether symptom clusters in patients with bone metastases vary when extracted using three different statistical methods. To compare the temporal composition of symptom clusters in responders versus non-responders to palliative radiation treatment.

METHODS: A previous dataset of 518 bone metastases patients who completed the Edmonton Symptom Assessment System (ESAS) was used in this study. Clusters derived using Principal Component Analysis (PCA) in our previous study were compared to symptom clusters extracted using Hierarchical Cluster Analysis (HCA) and Exploratory Factor Analysis (EFA). Clusters were derived at baseline, and 1, 2, 4, 8 and 12 weeks after radiation treatment. The patient sample was further divided into responders versus non-responders to radiotherapy. The three statistical methods were performed to identify clusters in the subgroups at each time point.

RESULTS: A complete consensus between HCA, EFA and PCA for the number and composition of symptom clusters was not reached at any time point. Furthermore, little correlation in clusters was found between the three statistical methods despite the use of an identical data set. As expected, different symptom clusters were observed in the responders and non-responders with all three statistical methods. In addition, clusters varied at each time point within each subgroup. Depression and anxiety were consistently found in the same cluster.

CONCLUSION: The quantity, composition, and occurrence of symptom clusters varied based on which statistical method was employed. The use of a common analytical method is necessary for consistency and comparison purposes in future symptom cluster research.

Keywords: Bone metastases; Edmonton symptom assessment system; Palliative radiotherapy.; Statistical analysis; Symptom cluster

Conflict of interest statement

The authors have no conflicts of interest to disclose.

References

  1. Oncol Nurs Forum. 2009 Nov;36(6):E282-92 - PubMed
  2. Cancer. 1997 Oct 15;80(8 Suppl):1588-94 - PubMed
  3. Support Care Cancer. 2007 Jan;15(1):39-46 - PubMed
  4. Genetics. 2010 Nov;186(3):943-57 - PubMed
  5. Cancer Nurs. 2005 Jul-Aug;28(4):270-82; quiz 283-4 - PubMed
  6. Support Care Cancer. 2007 Sep;15(9):1035-43 - PubMed
  7. Radiother Oncol. 2002 Sep;64(3):275-80 - PubMed
  8. Res Nurs Health. 2009 Jun;32(3):345-60 - PubMed
  9. Ann Oncol. 2006 May;17(5):801-6 - PubMed
  10. Eur J Oncol Nurs. 2010 Dec;14(5):417-34 - PubMed
  11. J Pain Symptom Manage. 2006 Jan;31(1):85-95 - PubMed
  12. J Pain Symptom Manage. 2004 Oct;28(4):373-80 - PubMed
  13. Cancer Nurs. 2008 Sep-Oct;31(5):E1-10 - PubMed
  14. Oncol Nurs Forum. 2001 Apr;28(3):465-70 - PubMed
  15. Parasitol Res. 2010 Nov;107(6):1499-503 - PubMed
  16. Support Care Cancer. 2007 Sep;15(9):1011-3 - PubMed
  17. J Support Oncol. 2007 Oct;5(9):427-33, 436 - PubMed
  18. J Natl Cancer Inst Monogr. 2004;(32):98-102 - PubMed
  19. Oncol Nurs Forum. 2008 Sep;35(5):786-93 - PubMed

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