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Overbay DA, Kaya H, Lamoreaux WT, et al. A Review of Novel Systemic Therapies and Brain Radiosurgery for Metastatic Melanoma. World J Oncol. 2012;3(3):93-96doi: 10.4021/wjon506w.
Overbay, D. A., Kaya, H., Lamoreaux, W. T., Fairbanks, R. K., Mackay, A. R., Demakas, J. J., Cook, B. S., & Lee, C. M. (2012). A Review of Novel Systemic Therapies and Brain Radiosurgery for Metastatic Melanoma. World journal of oncology, 3(3), 93-96. https://doi.org/10.4021/wjon506w
Overbay, Dexter A, et al. "A Review of Novel Systemic Therapies and Brain Radiosurgery for Metastatic Melanoma." World journal of oncology vol. 3,3 (2012): 93-96. doi: https://doi.org/10.4021/wjon506w
Overbay DA, Kaya H, Lamoreaux WT, Fairbanks RK, Mackay AR, Demakas JJ, Cook BS, Lee CM. A Review of Novel Systemic Therapies and Brain Radiosurgery for Metastatic Melanoma. World J Oncol. 2012 Jun;3(3):93-96. doi: 10.4021/wjon506w. Epub 2012 Jul 05. PMID: 29147288; PMCID: PMC5649786.
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World J Oncol. 2012 Jun;3(3):93-96. doi: 10.4021/wjon506w. Epub 2012 Jul 05.

A Review of Novel Systemic Therapies and Brain Radiosurgery for Metastatic Melanoma.

World journal of oncology

Dexter A Overbay, Hakan Kaya, Wayne T Lamoreaux, Robert K Fairbanks, Alexander R Mackay, John J Demakas, Barton S Cook, Christopher M Lee

Affiliations

  1. Internal Medicine Residency Spokane, 101 W 8th Ave, Box 2555, Spokane WA, 99220-2555, USA.
  2. Cancer Care Northwest, 910 W 5th Ave, Suite 102, Spokane, WA 99204, USA.
  3. Gamma Knife of Spokane, 910 W 5th Ave, Suite 102, Spokane, WA 99204, USA.
  4. Mackay and Meyer MDs, Spokane, WA 99204, USA.
  5. Spokane Brain & Spine, Spokane, WA 99204, USA.

PMID: 29147288 PMCID: PMC5649786 DOI: 10.4021/wjon506w

Abstract

Melanoma is a prevalent and particularly aggressive form of skin cancer. Although local disease can be treated well with excision, metastatic extracranial and intracranial disease can be very difficult to treat. Systemic therapies for melanoma have only recently led to statistically significant increases in overall survival with drugs such as Ipilimumab and Vemurafenib. Additionally, melanoma has been classically described as a relatively radio-resistant malignancy. Because of the potential radio-resistance, stereotactic radiosurgery has been widely utilized for intracranial brain metastases and clinical data has revealed excellent rates of local tumor control and tolerability with these highly focused radiation doses.

Keywords: Giant ventral hernia; Hernia repair; Polypropylene mesh

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