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Xiong J, Wei X, Liu ZM, et al. One-Pot Synthesis of Polysubstituted Imidazoles via Sequential Staudinger/aza-Wittig/Ag(I)-Catalyzed Cyclization/Isomerization. J Org Chem. 2017;82(24):13735-13739doi: 10.1021/acs.joc.7b02606.
Xiong, J., Wei, X., Liu, Z. M., & Ding, M. W. (2017). One-Pot Synthesis of Polysubstituted Imidazoles via Sequential Staudinger/aza-Wittig/Ag(I)-Catalyzed Cyclization/Isomerization. The Journal of organic chemistry, 82(24), 13735-13739. https://doi.org/10.1021/acs.joc.7b02606
Xiong, Jun, et al. "One-Pot Synthesis of Polysubstituted Imidazoles via Sequential Staudinger/aza-Wittig/Ag(I)-Catalyzed Cyclization/Isomerization." The Journal of organic chemistry vol. 82,24 (2017): 13735-13739. doi: https://doi.org/10.1021/acs.joc.7b02606
Xiong J, Wei X, Liu ZM, Ding MW. One-Pot Synthesis of Polysubstituted Imidazoles via Sequential Staudinger/aza-Wittig/Ag(I)-Catalyzed Cyclization/Isomerization. J Org Chem. 2017 Dec 15;82(24):13735-13739. doi: 10.1021/acs.joc.7b02606. Epub 2017 Nov 28. PMID: 29148765.
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J Org Chem. 2017 Dec 15;82(24):13735-13739. doi: 10.1021/acs.joc.7b02606. Epub 2017 Nov 28.

One-Pot Synthesis of Polysubstituted Imidazoles via Sequential Staudinger/aza-Wittig/Ag(I)-Catalyzed Cyclization/Isomerization.

The Journal of organic chemistry

Jun Xiong, Xiao Wei, Zi-Ming Liu, Ming-Wu Ding

Affiliations

  1. Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University , Wuhan 430079, P. R. China.

PMID: 29148765 DOI: 10.1021/acs.joc.7b02606

Abstract

A new one-pot preparation of polysubstituted imidazoles by a Staudinger/aza-Wittig/Ag(I)-catalyzed cyclization/isomerization has been developed. The easily accessible propargylazide derivatives reacted with triphenylphosphine, isocyanates, and amines sequentially to produce the fully substituted imidazoles in good overall yields in the presence of catalytic amount of AgNO

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