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Wu HY, Chen JX, Tian HQ, et al. Serum 25-hydroxyvitamin D inversely associated with blood eosinophils in patients with persistent allergic rhinitis. Asia Pac Allergy. 2017;7(4):213-220doi: 10.5415/apallergy.2017.7.4.213.
Wu, H. Y., Chen, J. X., Tian, H. Q., Zhang, X. L., Bian, H. Y., & Cheng, L. (2017). Serum 25-hydroxyvitamin D inversely associated with blood eosinophils in patients with persistent allergic rhinitis. Asia Pacific allergy, 7(4), 213-220. https://doi.org/10.5415/apallergy.2017.7.4.213
Wu, Hai-Yan, et al. "Serum 25-hydroxyvitamin D inversely associated with blood eosinophils in patients with persistent allergic rhinitis." Asia Pacific allergy vol. 7,4 (2017): 213-220. doi: https://doi.org/10.5415/apallergy.2017.7.4.213
Wu HY, Chen JX, Tian HQ, Zhang XL, Bian HY, Cheng L. Serum 25-hydroxyvitamin D inversely associated with blood eosinophils in patients with persistent allergic rhinitis. Asia Pac Allergy. 2017 Oct;7(4):213-220. doi: 10.5415/apallergy.2017.7.4.213. Epub 2017 Oct 30. PMID: 29094019; PMCID: PMC5663749.
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Asia Pac Allergy. 2017 Oct;7(4):213-220. doi: 10.5415/apallergy.2017.7.4.213. Epub 2017 Oct 30.

Serum 25-hydroxyvitamin D inversely associated with blood eosinophils in patients with persistent allergic rhinitis.

Asia Pacific allergy

Hai-Yan Wu, Jin-Xiang Chen, Hui-Qin Tian, Xiu-Ling Zhang, Hai-Yan Bian, Lei Cheng

Affiliations

  1. Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China.
  2. Department of Otorhinolaryngology, Affiliated Jiangyin Hospital, Medical College of Southeast University, Jiangyin 214400, Jiangsu, China.
  3. International Centre for Allergy Research, Nanjing Medical University, Nanjing 210029, Jiangsu, China.

PMID: 29094019 PMCID: PMC5663749 DOI: 10.5415/apallergy.2017.7.4.213

Abstract

OBJECTIVE: The relationship between vitamin D and allergic rhinitis (AR) remains unclear. The present study investigated their association by examining serum 25-hydroxyvitamin D (25(OH)D) levels, blood eosinophils, and the expression of vitamin D receptors (VDR) on nasal mucosa in patients with AR.

METHODS: A total of 32 patients with persistent AR and 25 controls were enrolled in this study. Serum 25(OH)D levels were detected by enzyme-linked immunosorbent assay, and eosinophils in the peripheral blood were examined by an automated hematology system, while VDR expression on inferior turbinate mucosa was assessed by immunohistochemistry. Furthermore, the correlation of serum 25(OH)D levels with blood eosinophils in persistent AR was analyzed.

RESULTS: No significant difference in serum 25(OH)D levels was detected between the AR and control groups (

CONCLUSION: These results suggest that the serum 25(OH)D might be inversely associated with blood eosinophils in patients with persistent AR. However, the relationship between vitamin D and AR still requires further clarification.

Keywords: 25-hydroxyvitamin D; Eosinophils; Nasal mucosa; Rhinitis, allergic; Vitamin D; Vitamin D receptors

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