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Chang Y, Tolani B, Nie X, et al. Review of the clinical applications and technological advances of circulating tumor DNA in cancer monitoring. Ther Clin Risk Manag. 2017;13:1363-1374doi: 10.2147/TCRM.S141991.
Chang, Y., Tolani, B., Nie, X., Zhi, X., Hu, M., & He, B. (2017). Review of the clinical applications and technological advances of circulating tumor DNA in cancer monitoring. Therapeutics and clinical risk management, 131363-1374. https://doi.org/10.2147/TCRM.S141991
Chang, Yi, et al. "Review of the clinical applications and technological advances of circulating tumor DNA in cancer monitoring." Therapeutics and clinical risk management vol. 13 (2017): 1363-1374. doi: https://doi.org/10.2147/TCRM.S141991
Chang Y, Tolani B, Nie X, Zhi X, Hu M, He B. Review of the clinical applications and technological advances of circulating tumor DNA in cancer monitoring. Ther Clin Risk Manag. 2017 Oct 11;13:1363-1374. doi: 10.2147/TCRM.S141991. eCollection 2017. PMID: 29066904; PMCID: PMC5644666.
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Ther Clin Risk Manag. 2017 Oct 11;13:1363-1374. doi: 10.2147/TCRM.S141991. eCollection 2017.

Review of the clinical applications and technological advances of circulating tumor DNA in cancer monitoring.

Therapeutics and clinical risk management

Yi Chang, Bhairavi Tolani, Xiuhong Nie, Xiuyi Zhi, Mu Hu, Biao He

Affiliations

  1. Department of Respiratory Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
  2. Thoracic Oncology Program, Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
  3. Department of Thoracic Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

PMID: 29066904 PMCID: PMC5644666 DOI: 10.2147/TCRM.S141991

Abstract

Circulating cell-free DNA (cfDNA) released by tumor cells, termed ctDNA, closely reflects the heterogeneity of primary cancers and their metastases. As a noninvasive, real-time monitoring biomarker, ctDNA is a promising tool for detecting driver gene mutations, assessing tumor burden and acquired resistance, and early diagnosis. However, isolation and enrichment of cfDNA is a big challenge due to the high degree of DNA fragmentation and its relatively low abundance in the bloodstream. This review aims to provide insights into the recent technological advances in acquisition of optimal quality cfDNA, the use of preservatives, isolation methods, processing timelines, and detection techniques. It also describes clinical applications of ctDNA in cancer patient management.

Keywords: biomarkers; cancer monitoring; circulating tumor DNA; ctDNA; liquid biopsy; targeted therapies; tumor heterogeneity

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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