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Panneton WM, Pan B, Gan Q. Somatotopy in the Medullary Dorsal Horn As a Basis for Orofacial Reflex Behavior. Front Neurol. 2017;8:522doi: 10.3389/fneur.2017.00522.
Panneton, W. M., Pan, B., & Gan, Q. (2017). Somatotopy in the Medullary Dorsal Horn As a Basis for Orofacial Reflex Behavior. Frontiers in neurology, 8522. https://doi.org/10.3389/fneur.2017.00522
Panneton, W Michael, et al. "Somatotopy in the Medullary Dorsal Horn As a Basis for Orofacial Reflex Behavior." Frontiers in neurology vol. 8 (2017): 522. doi: https://doi.org/10.3389/fneur.2017.00522
Panneton WM, Pan B, Gan Q. Somatotopy in the Medullary Dorsal Horn As a Basis for Orofacial Reflex Behavior. Front Neurol. 2017 Oct 10;8:522. doi: 10.3389/fneur.2017.00522. eCollection 2017. PMID: 29066998; PMCID: PMC5641296.
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Front Neurol. 2017 Oct 10;8:522. doi: 10.3389/fneur.2017.00522. eCollection 2017.

Somatotopy in the Medullary Dorsal Horn As a Basis for Orofacial Reflex Behavior.

Frontiers in neurology

W Michael Panneton, BingBing Pan, Qi Gan

Affiliations

  1. Department of Anesthesiology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United States.
  2. Department of Pharmacological and Physiological Science, School of Medicine, Saint Louis University, St. Louis, MO, United States.
  3. Department of Anesthesiology, Hunan Provincial People's Hospital, Changsha, China.

PMID: 29066998 PMCID: PMC5641296 DOI: 10.3389/fneur.2017.00522

Abstract

The somatotopy of the trigeminocervical complex of the rat was defined as a basis for describing circuitry for reflex behaviors directed through the facial motor nucleus. Thus, transganglionic transport of horseradish peroxidase conjugates applied to individual nerves/peripheral receptive fields showed that nerves innervating oropharyngeal structures projected most rostrally, followed by nerves innervating snout, periocular, and then periauricular receptive fields most caudally. Nerves innervating mucosae or glabrous receptive fields terminated densely in laminae I, II, and V of the trigeminocervical complex, while those innervating hairy skin terminated in laminae I-V. Projections to lamina II exhibited the most focused somatotopy when individual cases were compared. Retrograde transport of FluoroGold (FG) deposited into the facial motor nucleus resulted in labeled neurons almost solely in lamina V of the trigeminocervical complex. The distribution of these labeled neurons paralleled the somatotopy of primary afferent fibers, e.g., those labeled after FG injections into a functional group of motoneurons innervating lip musculature were found most rostrally while those labeled after injections into motoneurons innervating snout, periocular and preauricular muscles, respectively, were found at progressively more caudal levels. Anterograde transport of injections of biotinylated dextran amine into lamina V at different rostrocaudal levels of the trigeminocervical complex confirmed the notion that the somatotopy of orofacial sensory fields parallels the musculotopy of facial motor neurons. These data suggest that neurons in lamina V are important interneurons in a simple orofacial reflex circuit consisting of a sensory neuron, interneuron and motor neuron. Moreover, the somatotopy of primary afferent fibers from the head and neck confirms the "onion skin hypothesis" and suggests rostral cervical dermatomes blend seamlessly with "cranial dermatomes." The transition area between subnucleus interpolaris and subnucleus caudalis is addressed while the paratrigeminal nucleus is discussed as an interface between the somatic and visceral nervous systems.

Keywords: facial motor nucleus; lamina V; onion skin theory; trigeminal; trigeminocervical complex

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