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Toprak C, Sirmagul B, Yigitaslan S. Functional Effects of Alagebrium (ALT-711)-Isolated Rat Carotid Artery. Eurasian J Med. 2017;49(3):188-192doi: 10.5152/eurasianjmed.2017.17046.
Toprak, C., Sirmagul, B., & Yigitaslan, S. (2017). Functional Effects of Alagebrium (ALT-711)-Isolated Rat Carotid Artery. The Eurasian journal of medicine, 49(3), 188-192. https://doi.org/10.5152/eurasianjmed.2017.17046
Toprak, Cigdem, et al. "Functional Effects of Alagebrium (ALT-711)-Isolated Rat Carotid Artery." The Eurasian journal of medicine vol. 49,3 (2017): 188-192. doi: https://doi.org/10.5152/eurasianjmed.2017.17046
Toprak C, Sirmagul B, Yigitaslan S. Functional Effects of Alagebrium (ALT-711)-Isolated Rat Carotid Artery. Eurasian J Med. 2017 Oct;49(3):188-192. doi: 10.5152/eurasianjmed.2017.17046. PMID: 29123442; PMCID: PMC5665628.
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Eurasian J Med. 2017 Oct;49(3):188-192. doi: 10.5152/eurasianjmed.2017.17046.

Functional Effects of Alagebrium (ALT-711)-Isolated Rat Carotid Artery.

The Eurasian journal of medicine

Cigdem Toprak, Basar Sirmagul, Semra Yigitaslan

Affiliations

  1. Department of Pharmacology, Eski?ehir Osmangazi University School of Medicine, Eski?ehir, Turkey.

PMID: 29123442 PMCID: PMC5665628 DOI: 10.5152/eurasianjmed.2017.17046

Abstract

OBJECTIVE: In our study, the effects of glycosylated protein cross-link breaker, alagebrium was investigated on isolated rat carotid artery using myography. Alagebrium showed vasodilator effect on carotid artery rings; particularly, this effect was significantly increased in endothelium-intact rings.

MATERIALS AND METHODS: To clarify the vasodilator mechanism of alagebrium, different antagonists such as N(G)-Nitro-L-arginine methyl ester (L-NAME), glibenclamide, indomethacin, metoprolol, propranolol, tetraethylammonium, and calcium channel activator BAYK-8644 were used to reverse this effect.

RESULTS: Relaxation% responses to alagebrium were more significantly increased in intact endothelium than in denuded arteries. Blocking vasodilation related to channels (K-ATP, PGI2, BKca) and receptors (ß1, ß2) did not reverse the relaxation response to alagebrium. Vasodilator response to alagebrium was only slightly decreased after L-NAME incubation and significantly decreased after BAYK-8644 incubation.

CONCLUSION: Results of present study suggest that the mechanism of alagebrium-induced vasodilator effect may include the blockage of L-type calcium channels and partially of the nitric oxide synthase enzyme.

Keywords: Alagebrium; calcium channel blockage; carotid artery; nitric oxide; vasodilatation

Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

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