Display options
Cite
Gudowska M, Gruszewska E, Panasiuk A, et al. High serum N-terminal propeptide of procollagen type III concentration is associated with liver diseases. Prz Gastroenterol. 2017;12(3):203-207doi: 10.5114/pg.2017.70474.
Gudowska, M., Gruszewska, E., Panasiuk, A., Cylwik, B., Swiderska, M., Flisiak, R., Szmitkowski, M., & Chrostek, L. (2017). High serum N-terminal propeptide of procollagen type III concentration is associated with liver diseases. Przeglad gastroenterologiczny, 12(3), 203-207. https://doi.org/10.5114/pg.2017.70474
Gudowska, Monika, et al. "High serum N-terminal propeptide of procollagen type III concentration is associated with liver diseases." Przeglad gastroenterologiczny vol. 12,3 (2017): 203-207. doi: https://doi.org/10.5114/pg.2017.70474
Gudowska M, Gruszewska E, Panasiuk A, Cylwik B, Swiderska M, Flisiak R, Szmitkowski M, Chrostek L. High serum N-terminal propeptide of procollagen type III concentration is associated with liver diseases. Prz Gastroenterol. 2017;12(3):203-207. doi: 10.5114/pg.2017.70474. Epub 2017 Sep 30. PMID: 29123582; PMCID: PMC5672709.
Copy Download .nbib Format: NLM
Share it on

Prz Gastroenterol. 2017;12(3):203-207. doi: 10.5114/pg.2017.70474. Epub 2017 Sep 30.

High serum N-terminal propeptide of procollagen type III concentration is associated with liver diseases.

Przeglad gastroenterologiczny

Monika Gudowska, Ewa Gruszewska, Anatol Panasiuk, Bogdan Cylwik, Magdalena Swiderska, Robert Flisiak, Maciej Szmitkowski, Lech Chrostek

Affiliations

  1. Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland.
  2. Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland.
  3. Department of Paediatric Laboratory Diagnostics, Medical University of Bialystok, Bialystok, Poland.

PMID: 29123582 PMCID: PMC5672709 DOI: 10.5114/pg.2017.70474

Abstract

INTRODUCTION: N-terminal propeptide of procollagen type III (PIIINP) is generated during the synthesis of type III collagen. PIIINP can be measured in the serum as an indicator of liver fibrosis and cirrhosis.

AIM: To evaluate the effect of liver diseases of different aetiologies and clinical severity of liver cirrhosis on the serum level of PIIINP.

MATERIAL AND METHODS: Patients with alcoholic cirrhosis (AC) - 63 subjects, non-alcoholic cirrhosis (NAC) - 31 and toxic hepatitis (HT) - 33 were studied. Cirrhotic patients were classified according to the Child-Pugh scale. The samples were analysed using the ELISA method.

RESULTS: The level of PIIINP was significantly higher in patients with alcoholic cirrhosis, non-alcoholic cirrhosis, and toxic hepatitis in comparison to the control group. There were no significant differences in the serum PIIINP levels between liver diseases and according to the severity of liver cirrhosis. PIIINP has the highest diagnostic power for the diagnosis of toxic hepatitis. The highest sensitivity was reached in alcoholic cirrhosis, but other diagnostic values (specificity, positive predictive value (PPV), negative predictive value (NPV), diagnostic accuracy (ACC)) in alcoholic cirrhosis were lower than that in toxic hepatitis. In the diagnosis of non-alcoholic cirrhosis PIIINP has low sensitivity, specificity, PPV, NPV, and ACC.

CONCLUSIONS: The serum PIIINP shows the alterations in liver diseases in comparison to healthy controls, but not between diseases. Taking the above into account we can suggest that PIIINP may be a useful test for the detection of liver diseases.

Keywords: N-terminal propeptide of procollagen type III; liver cirrhosis; non-invasive markers; toxic hepatitis

References

  1. World J Gastroenterol. 2005 Dec 14;11(46):7318-22 - PubMed
  2. J Hepatol. 2003 Aug;39(2):179-86 - PubMed
  3. J Frailty Aging. 2013;2(3):129-34 - PubMed
  4. Biochim Biophys Acta. 2013 Jul;1832(7):866-75 - PubMed
  5. J Clin Invest. 2005 Feb;115(2):209-18 - PubMed
  6. Biochem J. 1990 Mar 1;266(2):313-27 - PubMed
  7. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1852-6 - PubMed
  8. BMC Gastroenterol. 2011 Aug 17;11:91 - PubMed
  9. PLoS One. 2014 Sep 29;9(9):e108544 - PubMed
  10. Clin Chim Acta. 2010 Aug 5;411(15-16):1009-17 - PubMed
  11. J Viral Hepat. 2010 Aug;17(8):546-54 - PubMed
  12. Clin Chim Acta. 2007 Jun;381(2):107-13 - PubMed
  13. Liver Int. 2015 Feb;35(2):429-37 - PubMed
  14. Clin Chim Acta. 1994 Jun;227(1-2):37-43 - PubMed

Publication Types