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Shimazui T, Matsumura Y, Nakada TA, et al. Serum levels of interleukin-6 may predict organ dysfunction earlier than SOFA score. Acute Med Surg. 2017;4(3):255-261doi: 10.1002/ams2.263.
Shimazui, T., Matsumura, Y., Nakada, T. A., & Oda, S. (2017). Serum levels of interleukin-6 may predict organ dysfunction earlier than SOFA score. Acute medicine & surgery, 4(3), 255-261. https://doi.org/10.1002/ams2.263
Shimazui, Takashi, et al. "Serum levels of interleukin-6 may predict organ dysfunction earlier than SOFA score." Acute medicine & surgery vol. 4,3 (2017): 255-261. doi: https://doi.org/10.1002/ams2.263
Shimazui T, Matsumura Y, Nakada TA, Oda S. Serum levels of interleukin-6 may predict organ dysfunction earlier than SOFA score. Acute Med Surg. 2017 Mar 06;4(3):255-261. doi: 10.1002/ams2.263. eCollection 2017 Jul. PMID: 29123872; PMCID: PMC5674450.
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Acute Med Surg. 2017 Mar 06;4(3):255-261. doi: 10.1002/ams2.263. eCollection 2017 Jul.

Serum levels of interleukin-6 may predict organ dysfunction earlier than SOFA score.

Acute medicine & surgery

Takashi Shimazui, Yosuke Matsumura, Taka-Aki Nakada, Shigeto Oda

Affiliations

  1. Department of Emergency and Critical Care Medicine Chiba University Graduate School of Medicine Chiba Japan.

PMID: 29123872 PMCID: PMC5674450 DOI: 10.1002/ams2.263

Abstract

AIM: To investigate the clinical utility of interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) as predictive markers in consideration of the time-course changes in critically ill patients with organ dysfunction.

METHODS: Serum levels of IL-6, PCT, CRP, and Sequential Organ Failure Assessment (SOFA) scores were measured sequentially in 92 patients during their initial 5 days following admission to the intensive care unit. Maximum values were analyzed. Patients were assigned to a low ( ≤ 8), intermediate ( > 8 and ≤ 16), or high ( > 16 and ≤ 24) SOFA score group.

RESULTS: There were significant differences in the maximum serum levels of IL-6 and PCT among the three SOFA score groups (IL-6,

CONCLUSION: Serum levels of IL-6 reflected the severity of organ dysfunction in critically ill patients most accurately compared to PCT and CRP. Interleukin-6 elevated soonest from the insult and reached its peak earlier than SOFA score.

Keywords: C‐reactive protein; critical illness; interleukin‐6; procalcitonin; sequential organ failure assessment scores

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