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da Silva RA, Sammartino Mariano F, Planello AC, et al. HaCaT anchorage blockade leads to oxidative stress, DNA damage and DNA methylation changes. Biochem Biophys Rep. 2015;2:94-102doi: 10.1016/j.bbrep.2015.05.008.
da Silva, R. A., Sammartino Mariano, F., Planello, A. C., Line, S. R. P., & de Souza, A. P. (2015). HaCaT anchorage blockade leads to oxidative stress, DNA damage and DNA methylation changes. Biochemistry and biophysics reports, 294-102. https://doi.org/10.1016/j.bbrep.2015.05.008
da Silva, Rodrigo A, et al. "HaCaT anchorage blockade leads to oxidative stress, DNA damage and DNA methylation changes." Biochemistry and biophysics reports vol. 2 (2015): 94-102. doi: https://doi.org/10.1016/j.bbrep.2015.05.008
da Silva RA, Sammartino Mariano F, Planello AC, Line SRP, de Souza AP. HaCaT anchorage blockade leads to oxidative stress, DNA damage and DNA methylation changes. Biochem Biophys Rep. 2015 May 30;2:94-102. doi: 10.1016/j.bbrep.2015.05.008. eCollection 2015 Jul. PMID: 29124149; PMCID: PMC5668640.
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Biochem Biophys Rep. 2015 May 30;2:94-102. doi: 10.1016/j.bbrep.2015.05.008. eCollection 2015 Jul.

HaCaT anchorage blockade leads to oxidative stress, DNA damage and DNA methylation changes.

Biochemistry and biophysics reports

Rodrigo A da Silva, Flavia Sammartino Mariano, Aline C Planello, Sergio R P Line, Ana Paula de Souza

Affiliations

  1. Department of Morphology, School of Dentistry of Piracicaba, University of Campinas - UNICAMP, Av. Limeira, 901, 13414-018 Piracicaba, SP, Brazil.

PMID: 29124149 PMCID: PMC5668640 DOI: 10.1016/j.bbrep.2015.05.008

Abstract

Cell adhesion plays an important role in neoplastic transformation. Thus, anchorage-independent growth and epithelial-mesenchymal transition, which are features associated to anoikis-resistance, are vital steps in cancer progression and metastatic colonization. Cell attachment loss may induce intracellular oxidative stress, which triggers DNA damage as methylation changes. HaCaT lineage cells were submitted to periods of 1, 3, 5 and 24 h of anchorage blockage with the purpose of study of oxidative stress effect on changes in the DNA methylation pattern, derived from attachment blockade. Through this study, HaCaT anchorage blockage-induced oxidative stress was reported to mediate alterations in global DNA methylation changes and into

Keywords: Anchorage blockade; Anoikis-resistance; DNA methylation; Epigenetics; Oxidative stress; Reactive oxygen species

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