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Imanikia S, Hylands P, Stürzenbaum SR. The double mutation of cytochrome P450's and fatty acid desaturases affect lipid regulation and longevity in . Biochem Biophys Rep. 2015;2:172-178doi: 10.1016/j.bbrep.2015.06.007.
Imanikia, S., Hylands, P., & Stürzenbaum, S. R. (2015). The double mutation of cytochrome P450's and fatty acid desaturases affect lipid regulation and longevity in . Biochemistry and biophysics reports, 2172-178. https://doi.org/10.1016/j.bbrep.2015.06.007
Imanikia, Soudabeh, et al. "The double mutation of cytochrome P450's and fatty acid desaturases affect lipid regulation and longevity in ." Biochemistry and biophysics reports vol. 2 (2015): 172-178. doi: https://doi.org/10.1016/j.bbrep.2015.06.007
Imanikia S, Hylands P, Stürzenbaum SR. The double mutation of cytochrome P450's and fatty acid desaturases affect lipid regulation and longevity in . Biochem Biophys Rep. 2015 Jun 25;2:172-178. doi: 10.1016/j.bbrep.2015.06.007. eCollection 2015 Jul. PMID: 29124160; PMCID: PMC5668661.
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Biochem Biophys Rep. 2015 Jun 25;2:172-178. doi: 10.1016/j.bbrep.2015.06.007. eCollection 2015 Jul.

The double mutation of cytochrome P450's and fatty acid desaturases affect lipid regulation and longevity in .

Biochemistry and biophysics reports

Soudabeh Imanikia, Peter Hylands, Stephen R Stürzenbaum

Affiliations

  1. Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, UK.
  2. Analytical and Environmental Sciences Division, Faculty of Life Sciences & Medicine, King's College London, London, UK.
  3. Institute of Pharmaceutical Science, Faculty of Life Sciences & Medicine, King's College London, London, UK.
  4. MRC-PHE Centre for Environment & Health, King's College London, London, UK.

PMID: 29124160 PMCID: PMC5668661 DOI: 10.1016/j.bbrep.2015.06.007

Abstract

An imbalance between energy uptake and energy expenditure can lead to obesity and increase the risk of coronary heart disease, high blood pressure, stroke, type II diabetes and some cancers. Given that key elements of the energy pathway are evolutionary conserved, invertebrate research is an attractive alternative that overcomes the many legislative, financial and experimental hurdles typical of research with higher metazoan animals. Recent studies have suggested that some members of the cytochrome P450 superfamily are involved in lipid metabolism in addition to the traditional xenobiotic activity. To investigate this notion in more detail, the present study aimed to pinpoint phenotypic, genetic and genomic-level responses of

Keywords: C. elegans; Cytochrome P450; Fatty acid desaturase; Life-span; Nematode

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