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Müller WEG, Tolba E, Dorweiler B, et al. Electrospun bioactive mats enriched with Ca-polyphosphate/retinol nanospheres as potential wound dressing. Biochem Biophys Rep. 2015;3:150-160doi: 10.1016/j.bbrep.2015.08.007.
Müller, W. E. G., Tolba, E., Dorweiler, B., Schröder, H. C., Diehl-Seifert, B., & Wang, X. (2015). Electrospun bioactive mats enriched with Ca-polyphosphate/retinol nanospheres as potential wound dressing. Biochemistry and biophysics reports, 3150-160. https://doi.org/10.1016/j.bbrep.2015.08.007
Müller, Werner E G, et al. "Electrospun bioactive mats enriched with Ca-polyphosphate/retinol nanospheres as potential wound dressing." Biochemistry and biophysics reports vol. 3 (2015): 150-160. doi: https://doi.org/10.1016/j.bbrep.2015.08.007
Müller WEG, Tolba E, Dorweiler B, Schröder HC, Diehl-Seifert B, Wang X. Electrospun bioactive mats enriched with Ca-polyphosphate/retinol nanospheres as potential wound dressing. Biochem Biophys Rep. 2015 Aug 10;3:150-160. doi: 10.1016/j.bbrep.2015.08.007. eCollection 2015 Sep. PMID: 29124179; PMCID: PMC5668879.
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Biochem Biophys Rep. 2015 Aug 10;3:150-160. doi: 10.1016/j.bbrep.2015.08.007. eCollection 2015 Sep.

Electrospun bioactive mats enriched with Ca-polyphosphate/retinol nanospheres as potential wound dressing.

Biochemistry and biophysics reports

Werner E G Müller, Emad Tolba, Bernhard Dorweiler, Heinz C Schröder, Bärbel Diehl-Seifert, Xiaohong Wang

Affiliations

  1. ERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, d-55128 Mainz, Germany.
  2. Division of Vascular Surgery, Department of Cardiothoracic and Vascular Surgery, University Medical Center of the Johannes Gutenberg University, Langenbeckstraße 1, d-55131 Mainz, Germany.
  3. NanotecMARIN GmbH, Duesbergweg 6, D-55128 Mainz, Germany.

PMID: 29124179 PMCID: PMC5668879 DOI: 10.1016/j.bbrep.2015.08.007

Abstract

BACKGROUND: While electrospun materials have been frequently used in tissue engineering no wound dressings exist that significantly improved wound healing effectively.

METHODS: We succeeded to fabricate three-dimensional (3D) electrospun poly(D,l-lactide) (PLA) fiber mats into which nanospheres, formed from amorphous calcium polyphosphate (polyP) nanoparticles (NP) and encapsulated retinol ("retinol/aCa-polyP-NS" nanospheres [NS]), had been incorporated.

RESULTS: Experiments with MC3T3-E1 cells revealed that co-incubation of the cells with Ca-polyP together with retinol (or incubation with retinol/aCa-polyP-NS) resulted in a significant synergistic effect on cell growth compared with particle-free polyP complexed with Ca

CONCLUSIONS: These results indicate that the PLA fibers, supplemented with aCa-polyP-NP or retinol/aCa-polyP-NS, elicit morphogenetic activity, suggesting that these fiber mats, along with the antibacterial effect of polyP, have a beneficial potential as wound dressings combining antimicrobial and regenerative (wound healing) properties.

GENERAL SIGNIFICANCE: The PLA-based fiber mats, containing retinol and polyP nanoparticles, provide promising bioactive meshes that are urgently needed as dressings for chronic wounds.

Keywords: Electrospinning; Polyphosphate; Retinol; Skin damage; Wound healing

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