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Lee BS, Lee BK, Iyer VR, et al. Corrected and Republished from: BCL11A Is a Critical Component of a Transcriptional Network That Activates RAG Expression and V(D)J Recombination. Mol Cell Biol. 2017;38(1)doi: 10.1128/MCB.00362-17.
Lee, B. S., Lee, B. K., Iyer, V. R., Sleckman, B. P., Shaffer, A. L., Ippolito, G. C., Tucker, H. O., & Dekker, J. D. (2018). Corrected and Republished from: BCL11A Is a Critical Component of a Transcriptional Network That Activates RAG Expression and V(D)J Recombination. Molecular and cellular biology, 38(1), . https://doi.org/10.1128/MCB.00362-17
Lee, Baeck-Seung, et al. "Corrected and Republished from: BCL11A Is a Critical Component of a Transcriptional Network That Activates RAG Expression and V(D)J Recombination." Molecular and cellular biology vol. 38,1 (2018). doi: https://doi.org/10.1128/MCB.00362-17
Lee BS, Lee BK, Iyer VR, Sleckman BP, Shaffer AL, Ippolito GC, Tucker HO, Dekker JD. Corrected and Republished from: BCL11A Is a Critical Component of a Transcriptional Network That Activates RAG Expression and V(D)J Recombination. Mol Cell Biol. 2017 Dec 13;38(1). doi: 10.1128/MCB.00362-17. Print 2018 Jan 01. PMID: 29038163; PMCID: PMC5730723.
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Mol Cell Biol. 2017 Dec 13;38(1). doi: 10.1128/MCB.00362-17. Print 2018 Jan 01.

Corrected and Republished from: BCL11A Is a Critical Component of a Transcriptional Network That Activates RAG Expression and V(D)J Recombination.

Molecular and cellular biology

Baeck-Seung Lee, Bum-Kyu Lee, Vishwanath R Iyer, Barry P Sleckman, Arthur L Shaffer, Gregory C Ippolito, Haley O Tucker, Joseph D Dekker

Affiliations

  1. Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas, USA.
  2. Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, USA.
  3. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
  4. Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
  5. Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas, USA [email protected] [email protected].

PMID: 29038163 PMCID: PMC5730723 DOI: 10.1128/MCB.00362-17

Abstract

Recombination activating gene 1 (RAG1) and RAG2 are critical enzymes for initiating variable-diversity-joining [V(D)J] segment recombination, an essential process for antigen receptor expression and lymphocyte development. The BCL11A transcription factor is required for B cell and plasmacytoid dendritic cell (pDC) development, but its molecular function(s) in early B cell fate specification and commitment is unknown. We show here that the major B cell isoform, BCL11A-XL, binds directly to the

Copyright © 2017 American Society for Microbiology.

Keywords: B cell development; Bcl11a; RAG; V(D)J; immunology

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