Acta Obstet Gynecol Scand. 1989 Jan;68:31-37. doi: 10.1111/aogs.1989.68.s150.31.
Acta obstetricia et gynecologica Scandinavica
L Mettler
PMID: 29124724 DOI: 10.1111/aogs.1989.68.s150.31
The etiology of genital endometriosis remains unclear, but it is evident that persisting endometriotic foci are stimulated by ovarian steroid hormones. Many cases are treated by surgery either via laparotomy or pelviscopy. Endocrine treatments with testosterone, gestagens, danazol and gestrinone have also been used to some effect. Recently developed analogs of gonadotropin-releasing hormone (GnRH) have demonstrated the high binding capacities of receptors involved in the down-regulation of the normal cycle which result in atrophy of the endometrium. These agents could therefore be used in the treatment of endometriosis. To date, 924 patients with pelvic endometriosis have been treated in our department with conventional endocrine therapies, 40 patients were treated with buserelin (D-Ser (Bu)
1989 Acta Obstet Gynecol Scand.
Keywords: Genital endometriosis; GnRH analogs; buserelin; danazol; gestrinone; goserelin
