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Tsuru M, Sata M, Tanaka M, et al. Retrospective Proteomic Analysis of a Novel, Cancer Metastasis-Promoting RGD-Containing Peptide. Transl Oncol. 2017;10(6):998-1007doi: 10.1016/j.tranon.2017.10.001.
Tsuru, M., Sata, M., Tanaka, M., Umeyama, H., Kodera, Y., Shiwa, M., Aoyagi, N., Yasuda, K., Matsuoka, K., Fukuda, T., Yamana, H., & Nagata, K. (2017). Retrospective Proteomic Analysis of a Novel, Cancer Metastasis-Promoting RGD-Containing Peptide. Translational oncology, 10(6), 998-1007. https://doi.org/10.1016/j.tranon.2017.10.001
Tsuru, Michiyo, et al. "Retrospective Proteomic Analysis of a Novel, Cancer Metastasis-Promoting RGD-Containing Peptide." Translational oncology vol. 10,6 (2017): 998-1007. doi: https://doi.org/10.1016/j.tranon.2017.10.001
Tsuru M, Sata M, Tanaka M, Umeyama H, Kodera Y, Shiwa M, Aoyagi N, Yasuda K, Matsuoka K, Fukuda T, Yamana H, Nagata K. Retrospective Proteomic Analysis of a Novel, Cancer Metastasis-Promoting RGD-Containing Peptide. Transl Oncol. 2017 Dec;10(6):998-1007. doi: 10.1016/j.tranon.2017.10.001. Epub 2017 Nov 02. PMID: 29096248; PMCID: PMC5671418.
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Transl Oncol. 2017 Dec;10(6):998-1007. doi: 10.1016/j.tranon.2017.10.001. Epub 2017 Nov 02.

Retrospective Proteomic Analysis of a Novel, Cancer Metastasis-Promoting RGD-Containing Peptide.

Translational oncology

Michiyo Tsuru, Michio Sata, Maki Tanaka, Hideaki Umeyama, Yoshio Kodera, Mieko Shiwa, Norikazu Aoyagi, Kaori Yasuda, Kei Matsuoka, Takaaki Fukuda, Hideaki Yamana, Kensei Nagata

Affiliations

  1. Clinical Proteomics and Gene Therapy Laboratory, Kurume University, Kurume, Japan; Research Center for Innovative Cancer Therapy, Kurume University, Kurume, Japan; Department of Orthopedic Surgery, Kurume University School of Medicine, Kurume, Japan. Electronic address: [email protected].
  2. Research Center for Innovative Cancer Therapy, Kurume University, Kurume, Japan; Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan.
  3. Department of Surgery, Kurume General Hospital, Kurume, Japan.
  4. Department of Biological Science, Chuo University, Tokyo, Japan.
  5. Department of Physics, School of Science, Kitasato University, Kanagawa, Japan.
  6. Life Science Division, Bio-Rad Laboratories K.K., Tokyo, Japan.
  7. Cell Innovator Co., Ltd., Fukuoka, Japan.
  8. Research Center for Innovative Cancer Therapy, Kurume University, Kurume, Japan; Department of Urology, Kurume University, Kurume, Japan.
  9. Center for Rheumatology, Kurume University School of Medicine, Kurume, Japan.
  10. Research Center for Innovative Cancer Therapy, Kurume University, Kurume, Japan; Center for Multidisciplinary Treatment of Cancer, Kurume University School of Medicine, Kurume, Japan.
  11. Clinical Proteomics and Gene Therapy Laboratory, Kurume University, Kurume, Japan; Research Center for Innovative Cancer Therapy, Kurume University, Kurume, Japan; Department of Orthopedic Surgery, Kurume University School of Medicine, Kurume, Japan.

PMID: 29096248 PMCID: PMC5671418 DOI: 10.1016/j.tranon.2017.10.001

Abstract

Patients who undergo surgical extirpation of a primary liver carcinoma followed by radiotherapy and chemotherapy leading to complete remission are nevertheless known to develop cancerous metastases 3-10 years later. We retrospectively examined the blood sera collected over 8 years from 30 patients who developed bone metastases after the complete remission of liver cancer to identify serum proteins showing differential expression compared to patients without remission. We detected a novel RGD (Arg-Gly-Asp)-containing peptide derived from the C-terminal portion of fibrinogen in the sera of metastatic patients that appeared to control the EMT (epithelial-mesenchymal transition) of cancer cells, in a process associated with miR-199a-3p. The RGD peptide enhanced new blood vessel growth and increased vascular endothelial growth factor levels when introduced into fertilized chicken eggs. The purpose of this study was to enable early detection of metastatic cancer cells using the novel RGD peptide as a biomarker, and thereby develop new drugs for the treatment of metastatic cancer.

Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

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