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Sadaka F, EthmaneAbouElMaali C, Cytron MA, et al. Predicting Mortality of Patients With Sepsis: A Comparison of APACHE II and APACHE III Scoring Systems. J Clin Med Res. 2017;9(11):907-910doi: 10.14740/jocmr3083w.
Sadaka, F., EthmaneAbouElMaali, C., Cytron, M. A., Fowler, K., Javaux, V. M., & O'Brien, J. (2017). Predicting Mortality of Patients With Sepsis: A Comparison of APACHE II and APACHE III Scoring Systems. Journal of clinical medicine research, 9(11), 907-910. https://doi.org/10.14740/jocmr3083w
Sadaka, Farid, et al. "Predicting Mortality of Patients With Sepsis: A Comparison of APACHE II and APACHE III Scoring Systems." Journal of clinical medicine research vol. 9,11 (2017): 907-910. doi: https://doi.org/10.14740/jocmr3083w
Sadaka F, EthmaneAbouElMaali C, Cytron MA, Fowler K, Javaux VM, O'Brien J. Predicting Mortality of Patients With Sepsis: A Comparison of APACHE II and APACHE III Scoring Systems. J Clin Med Res. 2017 Nov;9(11):907-910. doi: 10.14740/jocmr3083w. Epub 2017 Oct 02. PMID: 29038667; PMCID: PMC5633090.
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J Clin Med Res. 2017 Nov;9(11):907-910. doi: 10.14740/jocmr3083w. Epub 2017 Oct 02.

Predicting Mortality of Patients With Sepsis: A Comparison of APACHE II and APACHE III Scoring Systems.

Journal of clinical medicine research

Farid Sadaka, Cheikh EthmaneAbouElMaali, Margaret A Cytron, Kimberly Fowler, Victoria M Javaux, Jacklyn O'Brien

Affiliations

  1. Mercy Hospital St Louis, St Louis University, St. Louis, MO, USA.

PMID: 29038667 PMCID: PMC5633090 DOI: 10.14740/jocmr3083w

Abstract

BACKGROUND: Acute Physiology, Age and Chronic Health Evaluation (APACHE) II and III scores were developed in 1985 and 1991, respectively, and are used mainly for critically ill patients of all disease categories admitted to the intensive care unit (ICU). They differ in how chronic health status is assessed, in the number of physiologic variables included (12 vs. 17), and in the total score. These two scoring systems have not been compared in predicting hospital mortality in patients with sepsis.

METHODS: We retrospectively identified all septic patients admitted to our 54-bed medical-surgical ICU between June 2009 and February 2014 using the APACHE outcomes database. We calculated correlation coefficients for APACHE II and APACHE III scores in predicting hospital mortality. Receiver-operating characteristic (ROC) curves were also used to assess the mortality predictions.

RESULTS: We identified a total of 2,054 septic patients. Average APACHE II score was 19 ± 7, and average APACHE III score was 68 ± 28. ICU mortality was 11.8% and hospital mortality was 18.3%. Both APACHE II (r = 0.41) and APACHE III scores (r = 0.44) had good correlations with hospital mortality. There was no statistically significant difference between the two correlations (P = 0.1). ROC area under the curve (AUC) was 0.80 (95% confidence interval (CI): 0.78 - 0.82) for APACHE II, and 0.83 (95% CI: 0.81 - 0.85) for APACHE III, suggesting that both scores have very good discriminative powers for predicting hospital mortality.

CONCLUSIONS: This study shows that both APACHE II and APACHE III scores in septic patients were very strong predictors of hospital mortality. APACHE II was as good as APACHE III in predicting hospital mortality in septic patients.

Keywords: APACHE; Acute physiologic and chronic health evaluation; Epidemiology; Mortality; Outcome; Sepsis

References

  1. Crit Care Med. 1981 Aug;9(8):591-7 - PubMed
  2. Crit Care. 2013 Apr 25;17(2):R65 - PubMed
  3. Crit Care Med. 2017 Mar;45(3):486-552 - PubMed
  4. Crit Care Med. 1989 May;17(5):418-22 - PubMed
  5. JAMA. 2016 Feb 23;315(8):762-74 - PubMed
  6. Arch Surg. 1995 Jan;130(1):77-82 - PubMed
  7. JAMA. 1993 Nov 24;270(20):2478-86 - PubMed
  8. Intensive Care Med. 1996 Jun;22(6):559-63 - PubMed
  9. Crit Care Med. 1995 Aug;23(8):1327-35 - PubMed
  10. Intensive Care Med. 1994 May;20(5):390-7 - PubMed
  11. Crit Care Med. 2001 Jul;29(7):1303-10 - PubMed
  12. Intensive Care Med. 1997 Jan;23(1):77-84 - PubMed
  13. Crit Care Med. 1985 Jul;13(7):519-25 - PubMed
  14. Am J Respir Crit Care Med. 2003 Jul 15;168(2):165-72 - PubMed
  15. JAMA. 1993 Dec 22-29;270(24):2957-63 - PubMed
  16. J Formos Med Assoc. 2001 Jul;100(7):437-42 - PubMed
  17. N Engl J Med. 2003 Apr 17;348(16):1546-54 - PubMed
  18. Chest. 1991 Dec;100(6):1619-36 - PubMed
  19. J Trauma. 1991 Jul;31(7):915-8; discussion 918-9 - PubMed
  20. Intensive Care Med. 1995 Apr;21(4):302-9 - PubMed
  21. Crit Care Med. 1984 Nov;12(11):975-7 - PubMed
  22. Crit Care Med. 1985 Oct;13(10):818-29 - PubMed

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