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Chen RY, Lin YC, Chen SW, et al. Immunohistochemical biomarkers and volumetric parameters for predicting radiotherapy-based outcomes in patients with p16-negative pharyngeal cancer. Oncotarget. 2017;8(42):72342-72351doi: 10.18632/oncotarget.20374.
Chen, R. Y., Lin, Y. C., Chen, S. W., Lin, T. Y., Hsieh, T. C., Yen, K. Y., Liang, J. A., Yang, S. N., Wang, Y. C., Chen, Y. H., Chiang, S. F., & Kao, C. H. (2017). Immunohistochemical biomarkers and volumetric parameters for predicting radiotherapy-based outcomes in patients with p16-negative pharyngeal cancer. Oncotarget, 8(42), 72342-72351. https://doi.org/10.18632/oncotarget.20374
Chen, Rui-Yun, et al. "Immunohistochemical biomarkers and volumetric parameters for predicting radiotherapy-based outcomes in patients with p16-negative pharyngeal cancer." Oncotarget vol. 8,42 (2017): 72342-72351. doi: https://doi.org/10.18632/oncotarget.20374
Chen RY, Lin YC, Chen SW, Lin TY, Hsieh TC, Yen KY, Liang JA, Yang SN, Wang YC, Chen YH, Chiang SF, Kao CH. Immunohistochemical biomarkers and volumetric parameters for predicting radiotherapy-based outcomes in patients with p16-negative pharyngeal cancer. Oncotarget. 2017 Aug 21;8(42):72342-72351. doi: 10.18632/oncotarget.20374. eCollection 2017 Sep 22. PMID: 29069791; PMCID: PMC5641134.
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Oncotarget. 2017 Aug 21;8(42):72342-72351. doi: 10.18632/oncotarget.20374. eCollection 2017 Sep 22.

Immunohistochemical biomarkers and volumetric parameters for predicting radiotherapy-based outcomes in patients with p16-negative pharyngeal cancer.

Oncotarget

Rui-Yun Chen, Ying-Chun Lin, Shang-Wen Chen, Tze-Yi Lin, Te-Chun Hsieh, Kuo-Yang Yen, Ji-An Liang, Shih-Neng Yang, Yao-Ching Wang, Ya-Huey Chen, Shu-Fen Chiang, Chia-Hung Kao

Affiliations

  1. Department of Pathology, China Medical University Hospital, Taichung, Taiwan.
  2. Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan.
  3. The Ph.D. Program for Cancer Biology and Drug Discovery, China Medical University and Academia Sinica, Taichung, Taiwan.
  4. School of Medicine, China Medical University, Taichung, Taiwan.
  5. School of Medicine, Taipei Medical University, Taipei, Taiwan.
  6. Graduate Institute of Clinical Medical Science, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
  7. Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan.
  8. Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan.
  9. Graduate Institute of Cancer Biology, China Medical University, Taichung, Taiwan.
  10. Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan.
  11. Cancer Center, China Medical University Hospital, Taichung, Taiwan.
  12. Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan.

PMID: 29069791 PMCID: PMC5641134 DOI: 10.18632/oncotarget.20374

Abstract

BACKGROUND: This study determined the prognostic effects of immunohistochemical biomarkers and volumetric parameters predicting radiotherapy-based treatment in patients with p16-negative squamous cell carcinoma of the oropharynx or hypopharynx.

RESULTS: VEGF immunoreactivity > 2 and GLUT1 overexpression were prognostic factors for lower cause-specific survival. Moreover, both factors were associated with lower disease-free survival. The predictors of lower primary relapse-free survival were VEGF immunoreactivity > 2 and CT-based gross tumor volume > 16 mL.

MATERIALS AND METHODS: Immunohistochemical biomarkers in pretreatment biopsy specimens from 60 patients with p16-negative cancer were analyzed using tissue microarrays. Computed tomography (CT)-based and biological tumor volumes were retrieved through fluorodeoxyglucose positron emission tomography-CT. Correlations of cause-specific, disease-free, and primary relapse-free survival with volumetric parameters and the immunohistochemical biomarker score were investigated.

CONCLUSIONS: For patients with p16-negative pharyngeal cancer receiving radiotherapy, treatment outcomes can be stratified by VEGF and GLUT1 expression and CT-based gross tumor volume.

Keywords: biomarker; gross tumor volume; p16-negative pharyngeal cancer; positron emission tomography–computed tomography; squamous cell carcinoma

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest.

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