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Huang W, Zhang X, Li A, et al. Differential regulation of mRNAs and lncRNAs related to lipid metabolism in two pig breeds. Oncotarget. 2017;8(50):87539-87553doi: 10.18632/oncotarget.20978.
Huang, W., Zhang, X., Li, A., Xie, L., & Miao, X. (2017). Differential regulation of mRNAs and lncRNAs related to lipid metabolism in two pig breeds. Oncotarget, 8(50), 87539-87553. https://doi.org/10.18632/oncotarget.20978
Huang, Wanlong, et al. "Differential regulation of mRNAs and lncRNAs related to lipid metabolism in two pig breeds." Oncotarget vol. 8,50 (2017): 87539-87553. doi: https://doi.org/10.18632/oncotarget.20978
Huang W, Zhang X, Li A, Xie L, Miao X. Differential regulation of mRNAs and lncRNAs related to lipid metabolism in two pig breeds. Oncotarget. 2017 Sep 18;8(50):87539-87553. doi: 10.18632/oncotarget.20978. eCollection 2017 Oct 20. PMID: 29152100; PMCID: PMC5675652.
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Oncotarget. 2017 Sep 18;8(50):87539-87553. doi: 10.18632/oncotarget.20978. eCollection 2017 Oct 20.

Differential regulation of mRNAs and lncRNAs related to lipid metabolism in two pig breeds.

Oncotarget

Wanlong Huang, Xiuxiu Zhang, Ai Li, Lingli Xie, Xiangyang Miao

Affiliations

  1. State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

PMID: 29152100 PMCID: PMC5675652 DOI: 10.18632/oncotarget.20978

Abstract

Long non-coding RNAs (lncRNAs) can regulate lipid metabolism and adipogenesis. However, there is little research on the role of lncRNAs in fat deposition in pig. In this study, RNA-seq technology was used to analyze the gene expression profiles of subcutaneous adipose tissue in Laiwu (LW) and Large White (LY) pigs. Then, key lncRNAs and genes associated with lipid metabolism and adipogenic differentiation were identified. Fifty four lncRNAs and 482 known mRNAs were differentially expressed in the two pig breeds. GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analyses revealed that differentially expressed genes and the target genes of differentially expressed lncRNAs were significantly enriched in PPAR signaling pathway and biological processes including fat cell differentiation and fatty acid metabolism. Key lncRNAs might regulate adipogenic differentiation and fatty acid metabolism by regulating genes involved in above signaling pathway and biological processes. Specifically,

Keywords: RNA-seq; fat deposition; lncRNA; pig; subcutaneous adipose tissue

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that they have no competing interest.

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