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Wang H, Altemus J, Niazi F, et al. Breast tissue, oral and urinary microbiomes in breast cancer. Oncotarget. 2017;8(50):88122-88138doi: 10.18632/oncotarget.21490.
Wang, H., Altemus, J., Niazi, F., Green, H., Calhoun, B. C., Sturgis, C., Grobmyer, S. R., & Eng, C. (2017). Breast tissue, oral and urinary microbiomes in breast cancer. Oncotarget, 8(50), 88122-88138. https://doi.org/10.18632/oncotarget.21490
Wang, Hannah, et al. "Breast tissue, oral and urinary microbiomes in breast cancer." Oncotarget vol. 8,50 (2017): 88122-88138. doi: https://doi.org/10.18632/oncotarget.21490
Wang H, Altemus J, Niazi F, Green H, Calhoun BC, Sturgis C, Grobmyer SR, Eng C. Breast tissue, oral and urinary microbiomes in breast cancer. Oncotarget. 2017 Aug 14;8(50):88122-88138. doi: 10.18632/oncotarget.21490. eCollection 2017 Oct 20. PMID: 29152146; PMCID: PMC5675698.
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Oncotarget. 2017 Aug 14;8(50):88122-88138. doi: 10.18632/oncotarget.21490. eCollection 2017 Oct 20.

Breast tissue, oral and urinary microbiomes in breast cancer.

Oncotarget

Hannah Wang, Jessica Altemus, Farshad Niazi, Holly Green, Benjamin C Calhoun, Charles Sturgis, Stephen R Grobmyer, Charis Eng

Affiliations

  1. Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
  2. Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA.
  3. Surgical Oncology, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
  4. Department of Anatomic Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
  5. Comprehensive Breast Cancer Program, Cleveland Clinic, Cleveland, OH, USA.
  6. Germline High Risk Focus Group, CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  7. Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
  8. Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

PMID: 29152146 PMCID: PMC5675698 DOI: 10.18632/oncotarget.21490

Abstract

It has long been proposed that the gut microbiome contributes to breast carcinogenesis by modifying systemic estrogen levels. This is often cited as a possible mechanism linking breast cancer and high-fat, low-fiber diets as well as antibiotic exposure, associations previously identified in population-based studies. More recently, a distinct microbiome has been identified within breast milk and tissue, but few studies have characterized differences in the breast tissue microbiota of patients with and without cancer, and none have investigated distant body-site microbiomes outside of the gut. We hypothesize that cancerous breast tissue is associated with a microbiomic profile distinct from that of benign breast tissue, and that microbiomes of more distant sites, the oral cavity and urinary tract, will reflect dysbiosis as well. Fifty-seven women with invasive breast cancer undergoing mastectomy and 21 healthy women undergoing cosmetic breast surgery were enrolled. The bacterial 16S rRNA gene was amplified from urine, oral rinse and surgically collected breast tissue, sequenced, and processed through a QIIME-based bioinformatics pipeline. Cancer patient breast tissue microbiomes clustered significantly differently from non-cancer patients (

Keywords: breast cancer; metagenomics; microbiome; oral; urine

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that they have no relevant conflicts of interest.

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