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Henkin JM, Sydara K, Xayvue M, et al. Revisiting the linkage between ethnomedical use and development of new medicines: A novel plant collection strategy towards the discovery of anticancer agents. J Med Plant Res. 2017;11(40):621-634doi: 10.5897/jmpr2017.6485.
Henkin, J. M., Sydara, K., Xayvue, M., Souliya, O., Kinghorn, A. D., Burdette, J. E., Chen, W. L., Elkington, B. G., & Soejarto, D. D. (2017). Revisiting the linkage between ethnomedical use and development of new medicines: A novel plant collection strategy towards the discovery of anticancer agents. Journal of medicinal plant research, 11(40), 621-634. https://doi.org/10.5897/jmpr2017.6485
Henkin, Joshua M, et al. "Revisiting the linkage between ethnomedical use and development of new medicines: A novel plant collection strategy towards the discovery of anticancer agents." Journal of medicinal plant research vol. 11,40 (2017): 621-634. doi: https://doi.org/10.5897/jmpr2017.6485
Henkin JM, Sydara K, Xayvue M, Souliya O, Kinghorn AD, Burdette JE, Chen WL, Elkington BG, Soejarto DD. Revisiting the linkage between ethnomedical use and development of new medicines: A novel plant collection strategy towards the discovery of anticancer agents. J Med Plant Res. 2017 Oct;11(40):621-634. doi: 10.5897/jmpr2017.6485. Epub 2017 Oct 25. PMID: 29152156; PMCID: PMC5686776.
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J Med Plant Res. 2017 Oct;11(40):621-634. doi: 10.5897/jmpr2017.6485. Epub 2017 Oct 25.

Revisiting the linkage between ethnomedical use and development of new medicines: A novel plant collection strategy towards the discovery of anticancer agents.

Journal of medicinal plant research

Joshua M Henkin, Kongmany Sydara, Mouachanh Xayvue, Onevilay Souliya, A Douglas Kinghorn, Joanna E Burdette, Wei-Lun Chen, Bethany G Elkington, Djaja D Soejarto

Affiliations

  1. Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 S. Wood St., Chicago, Illinois 60612, USA.
  2. Institute of Traditional Medicine, Ministry of Health, Vientiane Capital, Lao People's Democratic Republic.
  3. Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Ohio State University, 500 W. 12th Ave., Columbus, OH 43210, USA.
  4. Science and Education, Field Museum, 1400 S. Lake Shore Drive, Chicago, Illinois 60605, USA.

PMID: 29152156 PMCID: PMC5686776 DOI: 10.5897/jmpr2017.6485

Abstract

The Vietnam-Laos International Cooperative Biodiversity Group (ICBG) based at the University of Illinois at Chicago (UIC) catalyzed a country-wide network of medicinal plant preserves (MPP) and medicinal biodiversity preserves (MBP) now established in ten provinces of the Lao People's Democratic Republic (Lao PDR), which are relied upon as protected sources of ethnomedicines for local villagers and traditional healers. In collaboration with the Lao PDR's Institute of Traditional Medicine (ITM), our ongoing P01 Program Project (Ohio State University) examined the anticancer bioprospecting potential for two of the most exhaustively inventoried of these sites: the Bolikhamxay MPP and the Xiengkhouang MBP. Guided by prior voucher specimens sourced from these preserves with an overwhelming emphasis on plants employed in traditional medicine, 201 distinct samples from 96 species were collected along with proper herbarium documentation. Aliquots of these plant samples were extracted in azeotropic ethanol and evaporated to dryness for initial biological evaluation. In six samples from six different species (2.99% of the collected samples, 6.25% of taxa) it was observed that extracts exhibited notable cytotoxicity against HT-29 colon adenocarcinoma cells. The wisdom behind the utilization of HT-29 cells in this preliminary biological screen is discussed. Furthermore, comparison of screening results based on longstanding considerations and ideological underpinnings of ethnobotanical vs. "random" biodiversity-based collection approaches is detailed herein. The results of this interdisciplinary study support the hypothesis that, by privileging the initial sample set in terms of human safety and pharmacological activity, ethnobotanically driven collection for biological screening efforts can produce leads unprecedented by the strict traditional usages of plants.

Keywords: Lao PDR; cancer; medicinal plants; traditional medicine

Conflict of interest statement

Conflict of interest The authors have not declared any conflict of interest.

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