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Meglio P, Giampietro PG, Carello R, et al. Oral immunotherapy in children with IgE-mediated hen's egg allergy: Follow-ups at 2.5 and 7 years. Allergy Rhinol (Providence). 2017;8(3):157-169doi: 10.2500/ar.2017.8.0211.
Meglio, P., Giampietro, P. G., Carello, R., & Galli, E. (2017). Oral immunotherapy in children with IgE-mediated hen's egg allergy: Follow-ups at 2.5 and 7 years. Allergy & rhinology (Providence, R.I.), 8(3), 157-169. https://doi.org/10.2500/ar.2017.8.0211
Meglio, Paolo, et al. "Oral immunotherapy in children with IgE-mediated hen's egg allergy: Follow-ups at 2.5 and 7 years." Allergy & rhinology (Providence, R.I.) vol. 8,3 (2017): 157-169. doi: https://doi.org/10.2500/ar.2017.8.0211
Meglio P, Giampietro PG, Carello R, Galli E. Oral immunotherapy in children with IgE-mediated hen's egg allergy: Follow-ups at 2.5 and 7 years. Allergy Rhinol (Providence). 2017 Oct 01;8(3):157-169. doi: 10.2500/ar.2017.8.0211. PMID: 29070273; PMCID: PMC5662541.
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Allergy Rhinol (Providence). 2017 Oct 01;8(3):157-169. doi: 10.2500/ar.2017.8.0211.

Oral immunotherapy in children with IgE-mediated hen's egg allergy: Follow-ups at 2.5 and 7 years.

Allergy & rhinology (Providence, R.I.)

Paolo Meglio, Paolo Gianni Giampietro, Rossella Carello, Elena Galli

Affiliations

  1. From the San Pietro Hospital, Fatebenefratelli Research Center, Rome, Italy.

PMID: 29070273 PMCID: PMC5662541 DOI: 10.2500/ar.2017.8.0211

Abstract

BACKGROUND: The present report was a follow-up investigation at 2.5- and 7-year intervals of a previous study of 20 children with moderate-to-severe immunoglobulin E (IgE) mediated hen's egg (HE) allergy who received oral immunotherapy (OIT) with raw HE. The study design of the previous study divided the 20 subjects into two groups of 10 each: (1) group 1, the OIT group (OIT-G), and, (2) group 2, an age-matched control group (C-G). In that study, 8 of 10 of the children in the OIT-G were successfully desensitized, one child was partially desensitized, and desensitization failed in one child. The aims of the present study were to evaluate the long-term effectiveness and safety profile of OIT with raw HE, and to assess the course and prognostic value of skin-prick tests (SPT) and serum-specific HE-IgEs in this study population.

METHODS: Of the 20 children who were recalled, 2 dropped out, which left 18 to be evaluated. Information on their HE intake was recorded, and SPTs with HE allergen extracts and with raw and hard-boiled HE were performed. Ovomucoid- and ovalbumin-specific IgE levels were also measured.

RESULTS: At the first (2.5-year) and second (7-year) follow-ups, 87.5% of the children in the OIT-G who tolerated raw HE were still tolerant, whereas the children in the C-G were significantly less tolerant. Overall, cutaneous sensitivity to HE significantly decreased after the 6-month desensitization period and at both follow-ups with regard to the OIT-G but not with regard to the C-G. A significant reduction in serum ovomucoid- and ovalbumin-specific IgE levels was seen in both the OIT-G and the C-G.

CONCLUSION: Clinical raw HE tolerance induced by OIT persists over time. Negativization of SPTs could be considered a more reliable prognostic indicator of clinical tolerance to raw HE than the reduction in specific-HE IgE levels. Raw-HE OIT would seem to be a promising method to treat HE allergy.

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