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Cassandri M, Smirnov A, Novelli F, et al. Zinc-finger proteins in health and disease. Cell Death Discov. 2017;3:17071doi: 10.1038/cddiscovery.2017.71.
Cassandri, M., Smirnov, A., Novelli, F., Pitolli, C., Agostini, M., Malewicz, M., Melino, G., & Raschellà, G. (2017). Zinc-finger proteins in health and disease. Cell death discovery, 317071. https://doi.org/10.1038/cddiscovery.2017.71
Cassandri, Matteo, et al. "Zinc-finger proteins in health and disease." Cell death discovery vol. 3 (2017): 17071. doi: https://doi.org/10.1038/cddiscovery.2017.71
Cassandri M, Smirnov A, Novelli F, Pitolli C, Agostini M, Malewicz M, Melino G, Raschellà G. Zinc-finger proteins in health and disease. Cell Death Discov. 2017 Nov 13;3:17071. doi: 10.1038/cddiscovery.2017.71. eCollection 2017. PMID: 29152378; PMCID: PMC5683310.
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Cell Death Discov. 2017 Nov 13;3:17071. doi: 10.1038/cddiscovery.2017.71. eCollection 2017.

Zinc-finger proteins in health and disease.

Cell death discovery

Matteo Cassandri, Artem Smirnov, Flavia Novelli, Consuelo Pitolli, Massimiliano Agostini, Michal Malewicz, Gerry Melino, Giuseppe Raschellà

Affiliations

  1. Department of Experimental Medicine and Surgery, University of Rome 'Tor Vergata', Rome 00133, Italy.
  2. Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, UK.
  3. ENEA Research Center Casaccia, Laboratory of Biosafety and Risk Assessment, Via Anguillarese, Rome, Italy.

PMID: 29152378 PMCID: PMC5683310 DOI: 10.1038/cddiscovery.2017.71

Abstract

Zinc-finger proteins (ZNFs) are one of the most abundant groups of proteins and have a wide range of molecular functions. Given the wide variety of zinc-finger domains, ZNFs are able to interact with DNA, RNA, PAR (poly-ADP-ribose) and other proteins. Thus, ZNFs are involved in the regulation of several cellular processes. In fact, ZNFs are implicated in transcriptional regulation, ubiquitin-mediated protein degradation, signal transduction, actin targeting, DNA repair, cell migration, and numerous other processes. The aim of this review is to provide a comprehensive summary of the current state of knowledge of this class of proteins. Firstly, we describe the actual classification of ZNFs, their structure and functions. Secondly, we focus on the biological role of ZNFs in the development of organisms under normal physiological and pathological conditions.

Conflict of interest statement

The authors declare no conflict of interest.

References

  1. J Clin Invest. 2006 Apr;116(4):929-39 - PubMed
  2. Nat Genet. 2006 Jun;38(6):682-7 - PubMed
  3. Cell Death Dis. 2016 Oct 20;7(10 ):e2428 - PubMed
  4. Eur J Cell Biol. 2016 Aug;95(8):277-84 - PubMed
  5. Cell Death Differ. 2016 Jan;23 (1):158-68 - PubMed
  6. Aging (Albany NY). 2015 Dec;7(12 ):1050-65 - PubMed
  7. J Biol Chem. 1996 Aug 16;271(33):20009-17 - PubMed
  8. Nat Rev Cancer. 2007 May;7(5):370-80 - PubMed
  9. Mol Carcinog. 2009 Jul;48(7):618-25 - PubMed
  10. Cell Mol Life Sci. 1999 Jan;55(1):96-107 - PubMed
  11. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3077-80 - PubMed
  12. Oncology. 2017;93(3):197-203 - PubMed
  13. Cancer Res. 2005 May 1;65(9):3811-4 - PubMed
  14. Nature. 2005 Jun 2;435(7042):646-51 - PubMed
  15. J Biomed Sci. 2016 Jul 13;23 (1):53 - PubMed
  16. Nature. 2003 Apr 17;422(6933):735-8 - PubMed
  17. Proc Natl Acad Sci U S A. 2012 Oct 2;109 (40):16202-7 - PubMed
  18. Oncotarget. 2014 Feb 28;5(4):872-81 - PubMed
  19. Biochem Biophys Res Commun. 2011 Sep 16;413(1):58-61 - PubMed
  20. Stem Cells. 2011 Nov;29(11):1705-16 - PubMed
  21. Mol Med. 1999 Feb;5(2):71-83 - PubMed
  22. Acta Biochim Biophys Sin (Shanghai). 2008 Jul;40(7):554-64 - PubMed
  23. Hum Genet. 2003 Dec;114(1):11-21 - PubMed
  24. Cell. 2011 Mar 4;144(5):689-702 - PubMed
  25. J Cell Biochem. 2015 Nov;116(11):2435-44 - PubMed
  26. Science. 2015 Jan 23;347(6220):1260419 - PubMed
  27. Hum Mol Genet. 2005 Apr 1;14(7):973-82 - PubMed
  28. Dev Cell. 2012 Mar 13;22(3):669-77 - PubMed
  29. Nucleic Acids Res. 2017 Feb 17;45(3):1114-1129 - PubMed
  30. Mol Cell Biol. 2005 Jan;25(2):706-15 - PubMed
  31. Elife. 2016 Oct 15;5:null - PubMed
  32. FEBS J. 2009 Aug;276(15):4197-206 - PubMed
  33. Cell Death Differ. 2016 Nov 1;23 (11):1886-1896 - PubMed
  34. Cell Death Differ. 2011 Nov;18(11):1791-804 - PubMed
  35. Genes Dev. 1997 Mar 15;11(6):714-25 - PubMed
  36. Cell Death Differ. 2016 Aug;23 (8):1296-311 - PubMed
  37. Mol Cell Biol. 1988 Apr;8(4):1684-96 - PubMed
  38. Cancer Chemother Pharmacol. 2006 Apr;57(4):491-9 - PubMed
  39. Oncotarget. 2017 Apr 24;8(31):51946-51962 - PubMed
  40. Cell Death Dis. 2015 Oct 29;6:e1947 - PubMed
  41. Cancer Res. 2016 Dec 1;76(23 ):6877-6887 - PubMed
  42. Bioessays. 2007 Jun;29(6):549-57 - PubMed
  43. Cell Death Differ. 2015 Jun;22(6):888-9 - PubMed
  44. Nature. 2012 Nov 1;491(7422):114-8 - PubMed
  45. Mod Pathol. 2009 Jan;22(1):66-70 - PubMed
  46. Hum Mol Genet. 2012 Jun 15;21(12):2745-58 - PubMed
  47. Oncogene. 2010 Jun 17;29(24):3490-500 - PubMed
  48. Oncol Lett. 2013 Feb;5(2):564-568 - PubMed
  49. Arch Otolaryngol Head Neck Surg. 2003 Jul;129(7):754-9 - PubMed
  50. Trends Genet. 1994 Sep;10(9):315-20 - PubMed
  51. Eur J Endocrinol. 2011 Mar;164(3):437-43 - PubMed
  52. Cell Death Dis. 2016 Jun 09;7(6):e2255 - PubMed
  53. J Pathol. 1997 May;182(1):54-61 - PubMed
  54. Oncol Rep. 2007 May;17(5):1089-94 - PubMed
  55. FEBS Lett. 2009 Jun 18;583(12):2108-13 - PubMed
  56. Cell Death Dis. 2016 Jun 16;7:e2266 - PubMed
  57. Cell Death Differ. 2008 May;15(5):841-8 - PubMed
  58. Cardiovasc Res. 2004 Aug 1;63(2):196-207 - PubMed
  59. Cancer Sci. 2012 Aug;103(8):1420-8 - PubMed
  60. Development. 2003 Jun;130(12):2767-77 - PubMed
  61. Cell Death Differ. 2015 Aug;22(8):1341-52 - PubMed
  62. Development. 1999 Feb;126(4):723-32 - PubMed
  63. Cell Death Differ. 2016 Dec;23 (12 ):1902-1903 - PubMed
  64. J Biol Chem. 2011 Jul 29;286(30):26516-23 - PubMed
  65. Cold Spring Harb Perspect Med. 2017 May 1;7(5):null - PubMed
  66. Cell Death Dis. 2015 Dec 31;6:e2035 - PubMed
  67. Protein Eng. 1988 Sep;2(3):209-18 - PubMed
  68. Nat Genet. 2006 Jul;38(7):749-51 - PubMed
  69. Nat Rev Mol Cell Biol. 2014 Mar;15(3):178-96 - PubMed
  70. J Biol Chem. 2001 Jan 12;276(2):1026-33 - PubMed
  71. J Biol Chem. 2009 Oct 23;284(43):29571-81 - PubMed
  72. J Cell Sci. 1994 Jun;107 ( Pt 6):1583-91 - PubMed
  73. Genes Dev. 1993 Jul;7(7A):1126-32 - PubMed
  74. Cancer Res. 2008 Jan 15;68(2):537-44 - PubMed
  75. Int J Cancer. 2001 Jan 1;91(1):8-21 - PubMed
  76. Cell Cycle. 2015 ;14 (4):481-7 - PubMed
  77. J Surg Oncol. 2012 Jun 15;105(8):830-4 - PubMed
  78. Hum Mol Genet. 2007 Dec 1;16(23 ):2972-86 - PubMed
  79. Biochim Biophys Acta. 2004 Nov 29;1695(1-3):235-47 - PubMed
  80. J Biol Chem. 2000 Apr 28;275(17):12879-88 - PubMed
  81. Science. 2003 May 2;300(5620):764 - PubMed
  82. Cell Death Differ. 2010 Feb;17(2):193-9 - PubMed
  83. Genomics. 1997 Aug 1;43(3):329-38 - PubMed
  84. Nucleic Acids Res. 2003 Jun 1;31(11):2900-14 - PubMed
  85. Development. 2002 Jun;129(11):2619-28 - PubMed
  86. FEBS J. 2015 Dec;282(23):4480-96 - PubMed
  87. Nat Genet. 2014 May;46(5):467-73 - PubMed
  88. Nat Rev Immunol. 2017 Feb;17 (2):130-143 - PubMed
  89. Biochem Biophys Res Commun. 1999 Aug 19;262(1):113-20 - PubMed
  90. Cancer Res. 2003 Jul 15;63(14 ):3877-82 - PubMed
  91. Q Rev Biophys. 2010 Feb;43(1):1-21 - PubMed
  92. PLoS One. 2013 Aug 21;8(8):e69378 - PubMed
  93. Curr Pharm Des. 2009;15(31):3681-96 - PubMed
  94. Genes Dev. 2014 Sep 15;28(18):2013-26 - PubMed
  95. Cell Death Dis. 2015 Apr 02;6:e1708 - PubMed
  96. BMC Med Genet. 2011 Dec 20;12:167 - PubMed
  97. EMBO J. 1997 Sep 15;16(18):5687-96 - PubMed
  98. Cell Death Differ. 2016 Aug;23 (8):1358-70 - PubMed
  99. Neurobiol Aging. 2004 Sep;25(8):991-9 - PubMed
  100. FEBS Lett. 2012 Jul 30;586(16):2294-9 - PubMed
  101. J Microbiol Biotechnol. 2016 Dec 28;26(12 ):2019-2029 - PubMed
  102. Oncogene. 2016 Jan 21;35(3):301-13 - PubMed
  103. J Cell Biochem. 2010 May 15;110(2):352-62 - PubMed
  104. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15608-12 - PubMed
  105. Dev Biol. 2016 Feb 1;410(1):86-97 - PubMed
  106. FEBS Lett. 2012 Jul 4;586(14):1959-70 - PubMed
  107. J Biol Chem. 2011 Nov 4;286(44):38190-201 - PubMed
  108. Development. 2014 Nov;141(21):4042-54 - PubMed
  109. Cell Death Dis. 2015 Oct 22;6:e1936 - PubMed
  110. Mol Cell Biol. 2007 Feb;27(3):1056-68 - PubMed
  111. Genes Dev. 1997 Apr 15;11(8):1061-72 - PubMed
  112. Gut. 2000 Apr;46(4):507-14 - PubMed
  113. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18668-73 - PubMed
  114. Nat Genet. 1997 Jan;15(1):30-5 - PubMed
  115. Oncogene. 2007 Jan 4;26(1):111-22 - PubMed
  116. Mol Cell Biol. 2006 Dec;26(23):9060-70 - PubMed
  117. Gastroenterology. 2011 Apr;140(4):1219-1229.e1-2 - PubMed
  118. J Muscle Res Cell Motil. 2014 Dec;35(5-6):259-65 - PubMed
  119. Cold Spring Harb Perspect Med. 2016 Jun 01;6(6):null - PubMed
  120. Immunol Rev. 2015 Jul;266(1):208-21 - PubMed
  121. Science. 2013 Feb 15;339(6121):819-23 - PubMed
  122. Cell Death Dis. 2015 Jul 16;6:e1821 - PubMed
  123. Mol Cell Biol. 2006 Mar;26(6):2055-64 - PubMed
  124. Cell Death Dis. 2015 Jul 02;6:e1802 - PubMed
  125. Nucleic Acids Res. 2015 Jan;43(Database issue):D1079-85 - PubMed
  126. J Invest Dermatol. 2006 Jan;126(1):49-60 - PubMed
  127. J Obstet Gynecol Neonatal Nurs. 2004 Jan-Feb;33(1):12-20 - PubMed
  128. Mol Cell Biol. 2016 Jun 29;36(14 ):1900-7 - PubMed
  129. Neurobiol Aging. 2012 Feb;33(2):422.e11-25 - PubMed
  130. PLoS One. 2012;7(8):e42628 - PubMed
  131. Pediatr Res. 2010 Oct;68(4):281-5 - PubMed
  132. Cell. 1995 Jan 13;80(1):155-65 - PubMed
  133. Nat Genet. 1999 Aug;22(4):356-60 - PubMed
  134. Oncogene. 2017 Jul 13;36(28):3943-3956 - PubMed
  135. Am J Hum Genet. 2015 Apr 2;96(4):597-611 - PubMed
  136. J Biol Chem. 2002 Aug 23;277(34):30901-13 - PubMed
  137. Oncogene. 2017 Apr 20;36(16):2243-2254 - PubMed
  138. Cell Death Discov. 2015;1:null - PubMed
  139. Mod Pathol. 2008 Aug;21(8):943-9 - PubMed
  140. Biochem Pharmacol. 2010 Jan 15;79(2):209-17 - PubMed
  141. EMBO J. 1998 Jan 15;17 (2):554-64 - PubMed
  142. Biochem Biophys Res Commun. 1997 Apr 7;233(1):154-60 - PubMed
  143. J Cell Physiol. 2017 May;232(5):1114-1122 - PubMed
  144. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13933-8 - PubMed
  145. Clin Cancer Res. 2001 May;7(5):1446-51 - PubMed
  146. Cell Death Differ. 2015 Sep;22(9):1517-25 - PubMed
  147. Oncogene. 2016 May 19;35(20):2592-601 - PubMed
  148. Mol Clin Oncol. 2014 Sep;2(5):709-713 - PubMed
  149. Nat Genet. 1997 Jan;15(1):21-9 - PubMed

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