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Rwei AY, Paris JL, Wang B, et al. Ultrasound-triggered local anaesthesia. Nat Biomed Eng. 2017;1:644-653doi: 10.1038/s41551-017-0117-6.
Rwei, A. Y., Paris, J. L., Wang, B., Wang, W., Axon, C. D., Vallet-Regí, M., Langer, R., & Kohane, D. S. (2017). Ultrasound-triggered local anaesthesia. Nature biomedical engineering, 1644-653. https://doi.org/10.1038/s41551-017-0117-6
Rwei, Alina Y, et al. "Ultrasound-triggered local anaesthesia." Nature biomedical engineering vol. 1 (2017): 644-653. doi: https://doi.org/10.1038/s41551-017-0117-6
Rwei AY, Paris JL, Wang B, Wang W, Axon CD, Vallet-Regí M, Langer R, Kohane DS. Ultrasound-triggered local anaesthesia. Nat Biomed Eng. 2017;1:644-653. doi: 10.1038/s41551-017-0117-6. Epub 2017 Aug 09. PMID: 29152410; PMCID: PMC5687284.
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Nat Biomed Eng. 2017;1:644-653. doi: 10.1038/s41551-017-0117-6. Epub 2017 Aug 09.

Ultrasound-triggered local anaesthesia.

Nature biomedical engineering

Alina Y Rwei, Juan L Paris, Bruce Wang, Weiping Wang, Christopher D Axon, María Vallet-Regí, Robert Langer, Daniel S Kohane

Affiliations

  1. Department of Anaesthesiology, Boston Children's Hospital, Boston, MA, 02115, USA.
  2. Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  3. Dpto. Química Inorgánica y Bioinorgánica, Facultad de Farmacia, UCM, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, 28040, Madrid, Spain.
  4. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Avenida Monforte de Lemos, 3-5, 28029, Madrid, Spain.
  5. Dr Li Dak-Sum Research Centre, The University of Hong Kong-Karolinska Institutet Collaboration in Regenerative Medicine, The University of Hong Kong, Hong Kong, China.
  6. David H. Koch Institutes for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  7. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  8. Department of Anaesthesiology, Boston Children's Hospital, Boston, MA, 02115, USA. [email protected].
  9. Laboratory for Biomaterials and Drug Delivery, Harvard Medical School, Boston, MA, 02115, USA. [email protected].

PMID: 29152410 PMCID: PMC5687284 DOI: 10.1038/s41551-017-0117-6

Abstract

On-demand relief of local pain would allow patients to control the timing, intensity and duration of nerve block in a safe and non-invasive manner. Ultrasound would be a suitable trigger for such a system, as it is in common clinical use and can penetrate deeply into the body. Here, we demonstrate that ultrasound-triggered delivery of an anaesthetic from liposomes allows the timing, intensity and duration of nerve block to be controlled by ultrasound parameters. On insonation, the encapsulated sonosensitizer protoporphyrin IX produces reactive oxygen species that react with the liposomal membrane, leading to the release of the potent local anaesthetic tetrodotoxin. We also show repeatable ultrasound-triggered nerve blocks

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