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Bhattacharya S, Gangaraju R, Chaum E. Recent Advances in Retinal Stem Cell Therapy. Curr Mol Biol Rep. 2017;3(3):172-182doi: 10.1007/s40610-017-0069-3.
Bhattacharya, S., Gangaraju, R., & Chaum, E. (2017). Recent Advances in Retinal Stem Cell Therapy. Current molecular biology reports, 3(3), 172-182. https://doi.org/10.1007/s40610-017-0069-3
Bhattacharya, Sujoy, et al. "Recent Advances in Retinal Stem Cell Therapy." Current molecular biology reports vol. 3,3 (2017): 172-182. doi: https://doi.org/10.1007/s40610-017-0069-3
Bhattacharya S, Gangaraju R, Chaum E. Recent Advances in Retinal Stem Cell Therapy. Curr Mol Biol Rep. 2017 Sep;3(3):172-182. doi: 10.1007/s40610-017-0069-3. Epub 2017 Jul 10. PMID: 29152454; PMCID: PMC5685516.
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Curr Mol Biol Rep. 2017 Sep;3(3):172-182. doi: 10.1007/s40610-017-0069-3. Epub 2017 Jul 10.

Recent Advances in Retinal Stem Cell Therapy.

Current molecular biology reports

Sujoy Bhattacharya, Rajashekhar Gangaraju, Edward Chaum

Affiliations

  1. Departments of Ophthalmology, and Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

PMID: 29152454 PMCID: PMC5685516 DOI: 10.1007/s40610-017-0069-3

Abstract

PURPOSE OF REVIEW: Progress in stem cell research for blinding diseases over the past decade is now being applied to patients with retinal degenerative diseases and soon perhaps, glaucoma. However, the field still has much to learn about the conversion of stem cells into various retinal cell types, and the potential delivery methods that will be required to optimize the clinical efficacy of stem cells delivered into the eye.

RECENT FINDINGS: Recent groundbreaking human clinical trials have demonstrated both the opportunities and current limitations of stem cell transplantation for retinal diseases. New progress in developing

SUMMARY: While promising progress is being made, meticulous clinical trials with cells derived using good manufacturing practice, novel surgical methods, and improved methods to derive all of the neuronal cell types present in the retina will be indispensable for developing stem cell transplantation as a paradigm shift for the treatment of blinding diseases.

Keywords: Age-related Macular Degeneration (AMD); Induced Pluripotent Stem Cells (iPSCs); Mesenchymal Stem Cells (MSCs); Photoreceptors; Retinal ganglion cells (RGCs); Retinal pigment epithelium (RPE)

Conflict of interest statement

Conflict of interests: SB: None; EC: None; RG is a scientific consultant and has financial interest in Cell Care Therapeutics, Inc. Conflict of Interest Sujoy Bhattacharya and Edward Chaum each declar

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