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Inci A, Olmaz R, Sarı F, et al. Increased oxidative stress in diabetic nephropathy and its relationship with soluble Klotho levels. Hippokratia. 2016;20(3):198-203
Inci, A., Olmaz, R., Sarı, F., Coban, M., Ellidag, H. Y., & Sarıkaya, M. (2016). Increased oxidative stress in diabetic nephropathy and its relationship with soluble Klotho levels. Hippokratia, 20(3), 198-203.
Inci, A, et al. "Increased oxidative stress in diabetic nephropathy and its relationship with soluble Klotho levels." Hippokratia vol. 20,3 (2016): 198-203.
Inci A, Olmaz R, Sarı F, Coban M, Ellidag HY, Sarıkaya M. Increased oxidative stress in diabetic nephropathy and its relationship with soluble Klotho levels. Hippokratia. 2016 Jul-Sep;20(3):198-203. PMID: 29097885; PMCID: PMC5654436.
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Hippokratia. 2016 Jul-Sep;20(3):198-203.

Increased oxidative stress in diabetic nephropathy and its relationship with soluble Klotho levels.

Hippokratia

A Inci, R Olmaz, F Sarı, M Coban, H Y Ellidag, M Sarıkaya

Affiliations

  1. Division of Nephrology, Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey.
  2. Division of Nephrology, Internal Medicine, Akdeniz University, Faculty of Medicine, Antalya, Turkey.
  3. Division of Biochemistry, Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey.

PMID: 29097885 PMCID: PMC5654436

Abstract

BACKGROUND: In the present study, we aimed to assess the relationship between the levels of soluble Klotho (s-Klotho) and oxidative stress markers in diabetic nephropathy patients with different stages of chronic kidney disease (CKD) and albuminuria levels.

METHODS: We enrolled 109 patients with type 2 diabetes (mean age, 61.63 ± 9.77 years) and 32 healthy controls (mean age, 49.53 ± 7.32 years) between January and June 2014.  Patients were classified into three groups based on their urinary albumin/creatinine ratio (UACR). Blood samples were collected to measure the levels of s-Klotho, serum creatinine, calcium, phosphorus, 25-hydroxyvitamin D3, and parathyroid hormone (PTH). We used the total oxidant status (TOS), total antioxidant status (TAS), ischemia-modified albumin (IMA), and ischemia-modified albumin ratio (IMAR) values to measure the oxidative status. Moreover, the oxidative stress index (OSI) was estimated as the percentage ratio of TOS/TAS values.

RESULTS: The TOS, TAS, and OSI values were significantly greater in the diabetic nephropathy patients compared to controls (p <0.001). When patients were classified based on their UACR, we noted that the TOS, OSI, and IMA values did not significantly differ, although the TAS (p <0.001), and IMAR (p =0.002) values significantly differed between the groups. The s-Klotho levels also significantly differed (p =0.031) between the groups. These s-Klotho levels exhibited a significant positive correlation with TOS (r =0.186, p =0.034) and OSI (r =0.207 p =0.018), but showed no correlation with the estimated glomerular filtration rate; UACR; HbA1c, calcium, phosphorus, and PTH levels; and TAS, IMA, and IMAR values.

CONCLUSION: Oxidative stress is greater in patients with diabetic nephropathy, and the TOS was positively correlated with s-Klotho levels in diabetic patients. The therapeutic reduction of oxidative stress in patients with diabetic nephropathy could improve the renal and cardiovascular outcomes. Hippokratia 2016, 20(3): 198-203.

Keywords: Diabetes; diabetic nephropathy; oxidative stress; s-Klotho; soluble Klotho

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