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Jannin A, Hennart B, Adenis A, et al. Life-Threatening Irinotecan-Induced Toxicity in an Adult Patient with Alveolar Rhabdomyosarcoma: The Role of a UGT1A1 Polymorphism. Case Rep Oncol Med. 2017;2017:2683478doi: 10.1155/2017/2683478.
Jannin, A., Hennart, B., Adenis, A., Chauffert, B., & Penel, N. (2017). Life-Threatening Irinotecan-Induced Toxicity in an Adult Patient with Alveolar Rhabdomyosarcoma: The Role of a UGT1A1 Polymorphism. Case reports in oncological medicine, 20172683478. https://doi.org/10.1155/2017/2683478
Jannin, Arnaud, et al. "Life-Threatening Irinotecan-Induced Toxicity in an Adult Patient with Alveolar Rhabdomyosarcoma: The Role of a UGT1A1 Polymorphism." Case reports in oncological medicine vol. 2017 (2017): 2683478. doi: https://doi.org/10.1155/2017/2683478
Jannin A, Hennart B, Adenis A, Chauffert B, Penel N. Life-Threatening Irinotecan-Induced Toxicity in an Adult Patient with Alveolar Rhabdomyosarcoma: The Role of a UGT1A1 Polymorphism. Case Rep Oncol Med. 2017;2017:2683478. doi: 10.1155/2017/2683478. Epub 2017 Sep 26. PMID: 29098099; PMCID: PMC5634569.
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Case Rep Oncol Med. 2017;2017:2683478. doi: 10.1155/2017/2683478. Epub 2017 Sep 26.

Life-Threatening Irinotecan-Induced Toxicity in an Adult Patient with Alveolar Rhabdomyosarcoma: The Role of a UGT1A1 Polymorphism.

Case reports in oncological medicine

Arnaud Jannin, Benjamin Hennart, Antoine Adenis, Bruno Chauffert, Nicolas Penel

Affiliations

  1. Lille II University Medical School, Lille, France.
  2. CHU Lille, Service de Toxicologie et Génopathies, Lille, France.
  3. Medical Oncology Department, Oscar Lambret Cancer Centre, Lille, France.
  4. Medical Oncology Department, Amiens University Hospital, Amiens, France.

PMID: 29098099 PMCID: PMC5634569 DOI: 10.1155/2017/2683478

Abstract

Alveolar rhabdomyosarcoma (AR) in adult patients is an exceptional malignancy. Management of AR is based on (neo)adjuvant chemotherapy combining ifosfamide, vincristine, and actinomycin D and local curative-intent surgery/radiotherapy. In cases of relapsing AR, the combination of temozolomide/irinotecan is regarded as a possible option. Here we describe life-threatening long-lasting toxicity related to the 1st cycle of irinotecan-based chemotherapy in a 56-year-old woman suffering from locally advanced and metastatic head and neck AR. The patient experienced grade 4 vomiting and diarrheas resulting in acute functional renal failure, associated with grade 4 neutropenia complicated by severe septic shock. The hospital stay duration was 40 days. The analysis of the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) gene revealed homozygous UGT1A1 

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