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J Biomed Inform. 2017 Dec;76:87-101. doi: 10.1016/j.jbi.2017.11.004. Epub 2017 Nov 07.

Logical comparison over RDF resources in bio-informatics.

Journal of biomedical informatics

S Colucci, F M Donini, E Di Sciascio

Affiliations

  1. Politecnico di Bari, Via Orabona 4, 70125 Bari, Italy. Electronic address: [email protected].
  2. Università della Tuscia, Via S. Maria in Gradi 4, 01100 Viterbo, Italy. Electronic address: [email protected].
  3. Politecnico di Bari, Via Orabona 4, 70125 Bari, Italy. Electronic address: [email protected].

PMID: 29127041 DOI: 10.1016/j.jbi.2017.11.004

Abstract

Comparison of resources is a frequent task in different bio-informatics applications, including drug-target interaction, drug repositioning and mechanism of action understanding, among others. This paper proposes a general method for the logical comparison of resources modeled in Resource Description Framework and shows its distinguishing features with reference to the comparison of drugs. In particular, the method returns a description of the commonalities between resources, rather than a numerical value estimating their similarity and/or relatedness. The approach is domain-independent and may be flexibly adapted to heterogeneous use cases, according to a process for setting parameters which is completely explicit. The paper also presents an experiment using the dataset Bioportal as knowledge source; the experiment is fully reproducible, thanks to the elicitation of criteria and values for parameter customization.

Copyright © 2017 Elsevier Inc. All rights reserved.

Keywords: Bioportal; Least common subsumer; Logical comparison; RDF; Web of data

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