Display options
Cite
Kalani A, Bami H, Tiboni M, et al. The effect of bariatric surgery on serum 25-OH vitamin D levels: a systematic review and meta-analysis. Obes Sci Pract. 2017;3(3):319-332doi: 10.1002/osp4.113.
Kalani, A., Bami, H., Tiboni, M., Jaeschke, R., Adachi, J. D., & Lau, A. N. (2017). The effect of bariatric surgery on serum 25-OH vitamin D levels: a systematic review and meta-analysis. Obesity science & practice, 3(3), 319-332. https://doi.org/10.1002/osp4.113
Kalani, A, et al. "The effect of bariatric surgery on serum 25-OH vitamin D levels: a systematic review and meta-analysis." Obesity science & practice vol. 3,3 (2017): 319-332. doi: https://doi.org/10.1002/osp4.113
Kalani A, Bami H, Tiboni M, Jaeschke R, Adachi JD, Lau AN. The effect of bariatric surgery on serum 25-OH vitamin D levels: a systematic review and meta-analysis. Obes Sci Pract. 2017 Jun 27;3(3):319-332. doi: 10.1002/osp4.113. eCollection 2017 Sep. PMID: 29071108; PMCID: PMC5598026.
Copy Download .nbib Format: NLM
Share it on

Obes Sci Pract. 2017 Jun 27;3(3):319-332. doi: 10.1002/osp4.113. eCollection 2017 Sep.

The effect of bariatric surgery on serum 25-OH vitamin D levels: a systematic review and meta-analysis.

Obesity science & practice

A Kalani, H Bami, M Tiboni, R Jaeschke, J D Adachi, A N Lau

Affiliations

  1. Department of Internal Medicine McMaster University Hamilton ON Canada.
  2. Schulich School of Medicine and Dentistry Western University London ON Canada.

PMID: 29071108 PMCID: PMC5598026 DOI: 10.1002/osp4.113

Abstract

BACKGROUND: Concerns have emerged about post-operative decreases in calcium and vitamin D following bariatric surgery. This review explores changes in metabolic bone health in persons with obesity undergoing gastric bypass surgery compared to non-surgical controls, providing an updated and comprehensive perspective on the literature.

METHODS: An electronic search was conducted in MEDLINE, Pubmed, EMBASE and Cochrane databases to 8 November 2016. Eligible trials included randomized controlled trials or controlled observational studies of patients who have undergone laparoscopic gastric bypass surgery. Statistical analysis was carried out using the Cochrane Collaboration Review Manager (RevMan 5.0), and a random effects model was implemented. Outcomes were expressed as weighted mean difference (WMD). The primary outcome examined was change in 25-OH-D levels at 12 months post surgery, and secondary outcomes included change in bone mineral density (BMD) measurements at 12 months post surgery at the lumbar spine (LS) and total hip (TH).

RESULTS: At 12 months, there was no significant difference in 25-OH vitamin D in the surgical group compared to controls (WMD = 6.79%; 95% CI: -9.01, 22.59;

CONCLUSIONS: Bariatric surgery may compromise metabolic bone health, but the paucity of high-quality literature limits conclusions.

Keywords: Bariatric surgery; metabolic bone disease; osteoporosis; vitamin d

References

  1. BMJ. 2000 Sep 9;321(7261):598-602 - PubMed
  2. Obes Surg. 2011 Apr;21(4):465-72 - PubMed
  3. J Gastrointest Surg. 2004 Jan;8(1):48-55; discussion 54-5 - PubMed
  4. Endocr Pract. 2013 Mar-Apr;19(2):337-72 - PubMed
  5. BMC Med Res Methodol. 2014 Dec 19;14:135 - PubMed
  6. J Bone Miner Res. 2012 Feb;27(2):294-300 - PubMed
  7. Osteoporos Int. 2014 Feb;25(2):423-39 - PubMed
  8. Am J Clin Nutr. 2000 Sep;72(3):690-3 - PubMed
  9. Obes Rev. 2015 Apr;16(4):341-9 - PubMed
  10. Obesity (Silver Spring). 2015 Dec;23(12):2344-8 - PubMed
  11. J Clin Endocrinol Metab. 2010 Nov;95(11):4823-43 - PubMed
  12. Lancet Diabetes Endocrinol. 2015 Jun;3(6):413-422 - PubMed
  13. Surg Obes Relat Dis. 2015 Mar-Apr;11(2):406-11 - PubMed
  14. J Bone Miner Res. 2014 Mar;29(3):542-50 - PubMed
  15. Lancet Diabetes Endocrinol. 2014 Feb;2(2):165-74 - PubMed
  16. Obes Sci Pract. 2017 Jun 27;3(3):319-332 - PubMed
  17. Clin Cases Miner Bone Metab. 2014 Jan;11(1):9-14 - PubMed
  18. Osteoporos Int. 2014 Jan;25(1):151-8 - PubMed
  19. Surg Obes Relat Dis. 2012 Mar-Apr;8(2):169-75 - PubMed
  20. J Clin Endocrinol Metab. 1988 Aug;67(2):373-8 - PubMed
  21. BMJ. 2011 Oct 18;343:d5928 - PubMed
  22. Medicine (Baltimore). 2015 Dec;94(48):e2087 - PubMed
  23. Metabolism. 2004 Jul;53(7):918-21 - PubMed
  24. Surg Obes Relat Dis. 2014 Nov-Dec;10(6):1056-62 - PubMed
  25. BMJ. 2012 Aug 03;345:e5085 - PubMed
  26. Obes Surg. 2005 Feb;15(2):145-54 - PubMed
  27. Saudi J Gastroenterol. 2015 Sep-Oct;21(5):269-77 - PubMed

Publication Types