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Sabini E, Leo M, Mazzi B, et al. Does Graves' Orbitopathy Ever Disappear? Answers to an Old Question. Eur Thyroid J. 2017;6(5):263-270doi: 10.1159/000477803.
Sabini, E., Leo, M., Mazzi, B., Rocchi, R., Latrofa, F., Nardi, M., Vitti, P., Marcocci, C., & Marinò, M. (2017). Does Graves' Orbitopathy Ever Disappear? Answers to an Old Question. European thyroid journal, 6(5), 263-270. https://doi.org/10.1159/000477803
Sabini, Elena, et al. "Does Graves' Orbitopathy Ever Disappear? Answers to an Old Question." European thyroid journal vol. 6,5 (2017): 263-270. doi: https://doi.org/10.1159/000477803
Sabini E, Leo M, Mazzi B, Rocchi R, Latrofa F, Nardi M, Vitti P, Marcocci C, Marinò M. Does Graves' Orbitopathy Ever Disappear? Answers to an Old Question. Eur Thyroid J. 2017 Sep;6(5):263-270. doi: 10.1159/000477803. Epub 2017 Jun 26. PMID: 29071239; PMCID: PMC5649266.
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Eur Thyroid J. 2017 Sep;6(5):263-270. doi: 10.1159/000477803. Epub 2017 Jun 26.

Does Graves' Orbitopathy Ever Disappear? Answers to an Old Question.

European thyroid journal

Elena Sabini, Marenza Leo, Barbara Mazzi, Roberto Rocchi, Francesco Latrofa, Marco Nardi, Paolo Vitti, Claudio Marcocci, Michele Marinò

Affiliations

  1. Endocrinology Units, Department of Clinical and Experimental Medicine, University of Pisa and University Hospital of Pisa, Pisa, Italy.
  2. Ophthalmopathy Unit I, Department of Surgical, Medical and Molecular Pathology, University of Pisa and University Hospital of Pisa, Pisa, Italy.

PMID: 29071239 PMCID: PMC5649266 DOI: 10.1159/000477803

Abstract

OBJECTIVES: There is a general belief that Graves' orbitopathy (GO) is a "chronic" disease, namely that patients' eyes do not return to how they were before GO appeared. Here, we investigate this issue from both the patient's and the physician's point of view.

STUDY DESIGN: We studied the disappearance of GO, regardless of treatment, in all consecutive patients with a GO history of at least 10 years who came for a follow-up visit over a period of 5 years. Patients underwent an ophthalmological examination and were asked to answer a questionnaire on self-perception related to GO.

RESULTS: We studied 99 consecutive patients with a GO duration ≥10 years. Between the first and the last observation, patients received several types of treatment for their thyroid disease and/or for GO. At the end of follow-up, GO was considered disappeared based on objective criteria in 8 patients (∼8%) and based on subjective criteria in 24 patients (∼24%). When we considered both subjective and objective criteria, only 2 patients (∼2%) had all criteria fulfilled and could be considered as GO-free.

CONCLUSIONS: GO is a chronic disease in the vast majority of patients. Even after a very long time since its onset, complete disappearance is rare, although a minority of patients believe they do not have GO anymore and an even lower proportion do not have relevant GO signs. Our findings have obvious implications in patient management and counseling.

Keywords: Autoimmunity; Graves' disease; Graves' orbitopathy; Thyroid

References

  1. J Endocrinol Invest. 2014 Nov;37(11):1041-8 - PubMed
  2. J Endocrinol Invest. 2017 Mar;40(3):281-287 - PubMed
  3. Optom Vis Sci. 2008 Oct;85(10):1012-7 - PubMed
  4. Clin Endocrinol (Oxf). 1997 Jul;47(1):9-14 - PubMed
  5. Clin Endocrinol (Oxf). 1995 Jan;42(1):45-50 - PubMed
  6. Orbit. 2004 Sep;23(3):161-8 - PubMed
  7. Thyroid. 2007 Jun;17(6):525-8 - PubMed
  8. Med Care. 1992 Jun;30(6):473-83 - PubMed
  9. N Engl J Med. 2010 Feb 25;362(8):726-38 - PubMed
  10. Eur Thyroid J. 2016 Mar;5(1):9-26 - PubMed
  11. J Clin Endocrinol Metab. 2013 Apr;98(4):1443-9 - PubMed
  12. CMAJ. 1987 Feb 15;136(4):369-72 - PubMed
  13. Br Med J. 1977 Jan 29;1(6056):273-5 - PubMed
  14. J Endocrinol Invest. 2017 May;40(5):547-553 - PubMed
  15. Health Policy. 1990 Dec;16(3):199-208 - PubMed
  16. Nat Rev Endocrinol. 2013 Dec;9(12):724-34 - PubMed
  17. J Endocrinol Invest. 2017 Mar;40(3):257-261 - PubMed
  18. Clin Exp Ophthalmol. 2009 Jul;37(5):496-502 - PubMed
  19. J Endocrinol Invest. 2016 Dec;39(12 ):1445-1451 - PubMed
  20. Eur J Ophthalmol. 2008 Mar-Apr;18(2):165-71 - PubMed
  21. Eur J Endocrinol. 2002 Jun;146(6):751-7 - PubMed
  22. Ophthalmology. 1996 Jun;103(6):958-62 - PubMed
  23. Metabolism. 1957 Jan;6(1):36-48 - PubMed
  24. Thyroid. 2014 Jan;24(1):60-6 - PubMed
  25. Clin Sci. 1945;5(3-4):177-94 - PubMed
  26. N Engl J Med. 2011 May 19;364(20):1920-31 - PubMed

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