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Uehara K, Iwashita H, Tanabe Y, et al. Esophageal Xanthoma: Presence of M2 Macrophages Suggests Association with Late Inflammatory and Reparative Processes. Open Med (Wars). 2017;12:335-339doi: 10.1515/med-2017-0048.
Uehara, K., Iwashita, H., Tanabe, Y., Kurima, K., Oshiro, M., Kina, S., Ota, A., Iwashita, A., & Kinjo, T. (2017). Esophageal Xanthoma: Presence of M2 Macrophages Suggests Association with Late Inflammatory and Reparative Processes. Open medicine (Warsaw, Poland), 12335-339. https://doi.org/10.1515/med-2017-0048
Uehara, Karina, et al. "Esophageal Xanthoma: Presence of M2 Macrophages Suggests Association with Late Inflammatory and Reparative Processes." Open medicine (Warsaw, Poland) vol. 12 (2017): 335-339. doi: https://doi.org/10.1515/med-2017-0048
Uehara K, Iwashita H, Tanabe Y, Kurima K, Oshiro M, Kina S, Ota A, Iwashita A, Kinjo T. Esophageal Xanthoma: Presence of M2 Macrophages Suggests Association with Late Inflammatory and Reparative Processes. Open Med (Wars). 2017 Oct 17;12:335-339. doi: 10.1515/med-2017-0048. eCollection 2017. PMID: 29071304; PMCID: PMC5651405.
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Open Med (Wars). 2017 Oct 17;12:335-339. doi: 10.1515/med-2017-0048. eCollection 2017.

Esophageal Xanthoma: Presence of M2 Macrophages Suggests Association with Late Inflammatory and Reparative Processes.

Open medicine (Warsaw, Poland)

Karina Uehara, Hidehiko Iwashita, Yasuka Tanabe, Kiyoto Kurima, Mariko Oshiro, Shinichiro Kina, Atsuko Ota, Akinori Iwashita, Takao Kinjo

Affiliations

  1. Division of Morphological Pathology, Department of Basic Laboratory Sciences, School of Health Sciences, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa903-0215, Japan.
  2. Department of Internal Medicine, Iwashita Medical Clinic, Okinawa, 904-2214Japan.
  3. Department of Regenerative Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, 903-0215Japan.
  4. Health Information Management Major, Management and Information Science Division, Faculty of International Studies, Meio University, Okinawa, 905-8585, Japan.
  5. Department of Oral and Maxillofacial Functional Rehabilitation, Graduate School of Medicine, University of the Ryukyus, Okinawa, 903-0215Japan.
  6. Department of Pathology, Fukuoka University Chikushi Hospital, Fukuoka, 818-0067Japan.

PMID: 29071304 PMCID: PMC5651405 DOI: 10.1515/med-2017-0048

Abstract

Esophageal xanthoma is a rare lesion which is an asymptomatic small yellowish polyp, and most of the reported cases were solitary lesion. Histologically, aggregations of foam cells are found under the papillary hypertrophic squamous epithelium and the foam cells express CD68. The etiology of esophageal xanthoma is unknown. The focal irritation of the esophageal mucosa and infiltrated inflammatory cells are presumed to contribute to its pathogenesis. Although the pathogenesis may be associated with inflammation, the type and nature of the macrophages remain unclear. Here we report a 46-year-old male with esophageal xanthoma, which was incidentally found by endoscopy. Histologically, acute inflammation was not noted, and immunohistochemistry revealed that the foam cells seen in this case of esophageal xanthoma expressed increased levels of M2 macrophage markers. These findings suggest that esophageal xanthoma is associated with late inflammatory and reparative processes long after the initial inflammation of esophageal squamous epithelium.

Keywords: Abnormalities; Diagnostic imaging; Esophagus; Pathology

Conflict of interest statement

Conflicts of interest: The authors declare that they have no conflicts of interest.

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