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Ozaki-Honda Y, Seki S, Fujiwara M, et al. Prognostic Prediction of Oral Squamous Cell Carcinoma by E-Cadherin and N-Cadherin Expression in Overall Cells in Tumor Nests or Tumor Cells at the Invasive Front. Cancer Microenviron. 2017;10(1):87-94doi: 10.1007/s12307-017-0201-1.
Ozaki-Honda, Y., Seki, S., Fujiwara, M., Matsuura, M., Fujita, S., Ikeda, H., Umeda, M., Ayuse, T., & Ikeda, T. (2017). Prognostic Prediction of Oral Squamous Cell Carcinoma by E-Cadherin and N-Cadherin Expression in Overall Cells in Tumor Nests or Tumor Cells at the Invasive Front. Cancer microenvironment : official journal of the International Cancer Microenvironment Society, 10(1), 87-94. https://doi.org/10.1007/s12307-017-0201-1
Ozaki-Honda, Yuu, et al. "Prognostic Prediction of Oral Squamous Cell Carcinoma by E-Cadherin and N-Cadherin Expression in Overall Cells in Tumor Nests or Tumor Cells at the Invasive Front." Cancer microenvironment : official journal of the International Cancer Microenvironment Society vol. 10,1 (2017): 87-94. doi: https://doi.org/10.1007/s12307-017-0201-1
Ozaki-Honda Y, Seki S, Fujiwara M, Matsuura M, Fujita S, Ikeda H, Umeda M, Ayuse T, Ikeda T. Prognostic Prediction of Oral Squamous Cell Carcinoma by E-Cadherin and N-Cadherin Expression in Overall Cells in Tumor Nests or Tumor Cells at the Invasive Front. Cancer Microenviron. 2017 Dec;10(1):87-94. doi: 10.1007/s12307-017-0201-1. Epub 2017 Nov 02. PMID: 29098659; PMCID: PMC5750204.
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Cancer Microenviron. 2017 Dec;10(1):87-94. doi: 10.1007/s12307-017-0201-1. Epub 2017 Nov 02.

Prognostic Prediction of Oral Squamous Cell Carcinoma by E-Cadherin and N-Cadherin Expression in Overall Cells in Tumor Nests or Tumor Cells at the Invasive Front.

Cancer microenvironment : official journal of the International Cancer Microenvironment Society

Yuu Ozaki-Honda, Sachiko Seki, Mutsunori Fujiwara, Masaaki Matsuura, Shuichi Fujita, Hisazumi Ikeda, Masahiro Umeda, Takao Ayuse, Tohru Ikeda

Affiliations

  1. Department of Oral Pathology and Bone Metabolism, Nagasaki University Graduate School of Biomedical Sciences, 1-5-8 Sakamoto, Nagasaki, Japan.
  2. Department of Clinical Physiology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  3. Department of Clinical Pathology, Japanese Red Cross Medical Center, Tokyo, Japan.
  4. Bioinformatics Group, Genome Center, Japanese Foundation for Cancer Research, Japan, and Graduate School of Public Health, Teikyo University, Tokyo, Japan.
  5. Department of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  6. Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
  7. Department of Oral Pathology and Bone Metabolism, Nagasaki University Graduate School of Biomedical Sciences, 1-5-8 Sakamoto, Nagasaki, Japan. [email protected].
  8. Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan. [email protected].

PMID: 29098659 PMCID: PMC5750204 DOI: 10.1007/s12307-017-0201-1

Abstract

Epithelial-mesenchymal transition (EMT) is a significant process in the invasion and metastasis of cancers including oral squamous cell carcinoma (OSCC), and the cadherin switch has been identified as one of the hallmarks of EMT. The aim of the present study was to evaluate the significance of the cadherin switch in the prognosis of OSCC and generate a model for prognostic predictions. Seventy-six biopsy and/or initial surgical specimens from OSCC patients were immunohistochemically analyzed for the expression of E-cadherin and N-cadherin in either overall OSCC cells in tumor nests or in OSCC cells at the invasive front. Among 76 OSCC cases, overall OSCC cells in tumor nests were negative for the expression of E-cadherin in 10 cases and positive for that of N-cadherin in 53 cases. Among 10 cases negative for the expression of E-cadherin, 4 cases were positive for that of N-cadherin. In OSCC cells at the invasive front, the expression of E-cadherin was negative in 62 cases, while that of N-cadherin was positive in 39 cases. Among 62 cases negative for the expression of E-cadherin, 33 cases were positive for that of N-cadherin. A logistic regression analysis showed that a model using the evaluation of N-cadherin expression in overall OSCC cells in tumor nests with a cut-off point of 70 years old was the best fit model. These results suggest that N-cadherin has significant value in prognostic predictions for OSCC patients.

Keywords: Cadherin; Epithelial-mesenchymal transition; Multivariate analysis; Oral squamous cell carcinoma; Prognosis

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