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Madan K, Tiwari P, Arava S, et al. Tracheobronchial puncture-site nodular reaction (TPNR) following endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA): Systematic review of case reports. Lung India. 2017;34(6):532-537doi: 10.4103/lungindia.lungindia_12_17.
Madan, K., Tiwari, P., Arava, S., Hadda, V., Mohan, A., & Guleria, R. (2017). Tracheobronchial puncture-site nodular reaction (TPNR) following endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA): Systematic review of case reports. Lung India : official organ of Indian Chest Society, 34(6), 532-537. https://doi.org/10.4103/lungindia.lungindia_12_17
Madan, Karan, et al. "Tracheobronchial puncture-site nodular reaction (TPNR) following endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA): Systematic review of case reports." Lung India : official organ of Indian Chest Society vol. 34,6 (2017): 532-537. doi: https://doi.org/10.4103/lungindia.lungindia_12_17
Madan K, Tiwari P, Arava S, Hadda V, Mohan A, Guleria R. Tracheobronchial puncture-site nodular reaction (TPNR) following endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA): Systematic review of case reports. Lung India. 2017 Nov-Dec;34(6):532-537. doi: 10.4103/lungindia.lungindia_12_17. PMID: 29098999; PMCID: PMC5684811.
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Lung India. 2017 Nov-Dec;34(6):532-537. doi: 10.4103/lungindia.lungindia_12_17.

Tracheobronchial puncture-site nodular reaction (TPNR) following endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA): Systematic review of case reports.

Lung India : official organ of Indian Chest Society

Karan Madan, Pavan Tiwari, Sudheer Arava, Vijay Hadda, Anant Mohan, Randeep Guleria

Affiliations

  1. Department of Pulmonary Medicine and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India.

PMID: 29098999 PMCID: PMC5684811 DOI: 10.4103/lungindia.lungindia_12_17

Abstract

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive and efficacious diagnostic modality for lung cancer staging and evaluation of undiagnosed mediastinal lymphadenopathy. Procedure-related complications are uncommon. We herein report an infrequently described phenomenon following EBUS-TBNA in which two patients developed nodular granulation tissue at the tracheobronchial puncture site. On systematic review, we found description of such phenomena by terminologies such as endobronchial inflammatory polyp, granuloma, and endobronchial mass. The endobronchial inflammatory polyp has been one of the most commonly used terminologies for these; but in most cases, the classical features of an inflammatory polyp are lacking. We propose the term, tracheobronchial puncture-site nodular reaction (TPNR) with further classification into granulomatous and nongranulomatous subtypes, for standardized reporting of such reactions following transbronchial needle aspiration procedures. Knowledge of this entity and standardized nomenclature shall help in better characterization of the outcomes and risk factors for the occurrence of these reactions.

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