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Greco G, Agostini M, Shilton R, et al. Surface Acoustic Wave (SAW)-Enhanced Chemical Functionalization of Gold Films. Sensors (Basel). 2017;17(11)doi: 10.3390/s17112452.
Greco, G., Agostini, M., Shilton, R., Travagliati, M., Signore, G., & Cecchini, M. (2017). Surface Acoustic Wave (SAW)-Enhanced Chemical Functionalization of Gold Films. Sensors (Basel, Switzerland), 17(11), . https://doi.org/10.3390/s17112452
Greco, Gina, et al. "Surface Acoustic Wave (SAW)-Enhanced Chemical Functionalization of Gold Films." Sensors (Basel, Switzerland) vol. 17,11 (2017). doi: https://doi.org/10.3390/s17112452
Greco G, Agostini M, Shilton R, Travagliati M, Signore G, Cecchini M. Surface Acoustic Wave (SAW)-Enhanced Chemical Functionalization of Gold Films. Sensors (Basel). 2017 Oct 26;17(11). doi: 10.3390/s17112452. PMID: 29072590; PMCID: PMC5713185.
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Sensors (Basel). 2017 Oct 26;17(11). doi: 10.3390/s17112452.

Surface Acoustic Wave (SAW)-Enhanced Chemical Functionalization of Gold Films.

Sensors (Basel, Switzerland)

Gina Greco, Matteo Agostini, Richie Shilton, Marco Travagliati, Giovanni Signore, Marco Cecchini

Affiliations

  1. National Enterprise for nanoScience and nanoTechnology (NEST), Istituto Nanoscienze-CNR and Scuola Normale Superiore, Piazza San Silvestro 12, 56127 Pisa, Italy. [email protected].
  2. National Enterprise for nanoScience and nanoTechnology (NEST), Istituto Nanoscienze-CNR and Scuola Normale Superiore, Piazza San Silvestro 12, 56127 Pisa, Italy. [email protected].
  3. Center for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, Italy. [email protected].
  4. Center for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, Italy. [email protected].
  5. National Enterprise for nanoScience and nanoTechnology (NEST), Istituto Nanoscienze-CNR and Scuola Normale Superiore, Piazza San Silvestro 12, 56127 Pisa, Italy. [email protected].
  6. Center for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, Italy. [email protected].
  7. National Enterprise for nanoScience and nanoTechnology (NEST), Istituto Nanoscienze-CNR and Scuola Normale Superiore, Piazza San Silvestro 12, 56127 Pisa, Italy. [email protected].
  8. Center for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12, 56127 Pisa, Italy. [email protected].
  9. National Enterprise for nanoScience and nanoTechnology (NEST), Istituto Nanoscienze-CNR and Scuola Normale Superiore, Piazza San Silvestro 12, 56127 Pisa, Italy. [email protected].

PMID: 29072590 PMCID: PMC5713185 DOI: 10.3390/s17112452

Abstract

Surface chemical and biochemical functionalization is a fundamental process that is widely applied in many fields to add new functions, features, or capabilities to a material's surface. Here, we demonstrate that surface acoustic waves (SAWs) can enhance the chemical functionalization of gold films. This is shown by using an integrated biochip composed by a microfluidic channel coupled to a surface plasmon resonance (SPR) readout system and by monitoring the adhesion of biotin-thiol on the gold SPR areas in different conditions. In the case of SAW-induced streaming, the functionalization efficiency is improved ≈ 5 times with respect to the case without SAWs. The technology here proposed can be easily applied to a wide variety of biological systems (e.g., proteins, nucleic acids) and devices (e.g., sensors, devices for cell cultures).

Keywords: functionalization; microfluidics; surface acoustic waves (SAWs)

Conflict of interest statement

The authors declare no conflict of interest.

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