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Grady D, Weiss M, Hernandez-Sanchez J, et al. Medication and patient factors associated with adherence to pulmonary hypertension targeted therapies. Pulm Circ. 2017;8(1):2045893217743616doi: 10.1177/2045893217743616.
Grady, D., Weiss, M., Hernandez-Sanchez, J., & Pepke-Zaba, J. (2018). Medication and patient factors associated with adherence to pulmonary hypertension targeted therapies. Pulmonary circulation, 8(1), 2045893217743616. https://doi.org/10.1177/2045893217743616
Grady, Duncan, et al. "Medication and patient factors associated with adherence to pulmonary hypertension targeted therapies." Pulmonary circulation vol. 8,1 (2018): 2045893217743616. doi: https://doi.org/10.1177/2045893217743616
Grady D, Weiss M, Hernandez-Sanchez J, Pepke-Zaba J. Medication and patient factors associated with adherence to pulmonary hypertension targeted therapies. Pulm Circ. 2018 Jan-Mar;8(1):2045893217743616. doi: 10.1177/2045893217743616. Epub 2017 Nov 03. PMID: 29099657; PMCID: PMC5731720.
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Pulm Circ. 2018 Jan-Mar;8(1):2045893217743616. doi: 10.1177/2045893217743616. Epub 2017 Nov 03.

Medication and patient factors associated with adherence to pulmonary hypertension targeted therapies.

Pulmonary circulation

Duncan Grady, Marjorie Weiss, Jules Hernandez-Sanchez, Joanna Pepke-Zaba

Affiliations

  1. 1 2144 Pharmacy Department, Papworth Hospital NHS Foundation Trust , Papworth Everard, UK.
  2. 2 2112 Department of Pharmacy and Pharmacology, University of Bath , Bath, UK.
  3. 3 2144 Papworth Trials Unit Collaboration, Papworth Hospital NHS Foundation Trust , Papworth Everard, UK.
  4. 4 2144 Pulmonary Vascular Disease Unit, Papworth Hospital NHS Foundation Trust , Papworth Everard, UK.

PMID: 29099657 PMCID: PMC5731720 DOI: 10.1177/2045893217743616

Abstract

The aims of this study were to investigate the medication adherence of patients on pulmonary hypertension (PH)-targeted therapies and uncover factors that might influence adherence values. Patients taking at least one specialist medicine (sildenafil, tadalafil, bosentan, ambrisentan, iloprost, epoprostenol, treprostinil) completed a Morisky Medication Adherence Scale-8 (MMAS-8) questionnaire. Participants' MMAS-8 scores were used to estimate overall medicine adherence. Potential adherence co-factor data were collected from patient databases and hospital discharge summaries. The MMAS-8 questionnaire was completed by 263 patients (mean age = 61.6 ± 14.8 years, 70.6% women). Data from MMAS-8 showed that 47.9% reported high adherence, 40.3% moderate adherence, and 11.8% low adherence. Factors associated with adherence as measured by the MMAS-8 included: older age; taking monotherapy; and having a higher number of co-morbidities or concurrent medicines. Higher administration frequency, greater length of time on targeted therapy, and use of a compliance aid had a negative association with adherence. Overall adherence to PH specialist medicines is relatively high but a proportion of patients report sub-optimal adherence behavior. A number of factors may help to recognize susceptible patients.

Keywords: MMAS-8; Morisky; compliance; concordance; medicines

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