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Unfer V, Facchinetti F, Orrù B, et al. Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials. Endocr Connect. 2017;6(8):647-658doi: 10.1530/EC-17-0243.
Unfer, V., Facchinetti, F., Orrù, B., Giordani, B., & Nestler, J. (2017). Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials. Endocrine connections, 6(8), 647-658. https://doi.org/10.1530/EC-17-0243
Unfer, Vittorio, et al. "Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials." Endocrine connections vol. 6,8 (2017): 647-658. doi: https://doi.org/10.1530/EC-17-0243
Unfer V, Facchinetti F, Orrù B, Giordani B, Nestler J. Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials. Endocr Connect. 2017 Nov;6(8):647-658. doi: 10.1530/EC-17-0243. PMID: 29042448; PMCID: PMC5655679.
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Endocr Connect. 2017 Nov;6(8):647-658. doi: 10.1530/EC-17-0243.

Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials.

Endocrine connections

Vittorio Unfer, Fabio Facchinetti, Beatrice Orrù, Barbara Giordani, John Nestler

Affiliations

  1. Health DepartmentUniPoliSi - Institut des Etudes Universitaires, Disentis, Switzerland [email protected].
  2. Mother-Infant DepartmentUniversity of Modena and Reggio Emilia, Modena, Italy.
  3. Medical Affairs DepartmentLo.Li. Pharma, Rome, Italy.
  4. Departments of Medicine and Obstetrics and GynecologyVirginia Commonwealth University, Richmond, Virginia, USA.

PMID: 29042448 PMCID: PMC5655679 DOI: 10.1530/EC-17-0243

Abstract

Myo-inositol (MI) supplementation in women with polycystic ovary syndrome (PCOS) has been evaluated over the last years. Many hormonal and reproductive impairments associated with this disorder seem relieved by the supplement. The objective of the meta-analysis was to assess the effects of MI alone or combined with d-chiro-inositol (DCI) on the endocrine and metabolic abnormalities of women with PCOS. Literature was retrieved from selected databases, MEDLINE, EMBASE, PubMed and Research Gate (up to November 2016). Only randomized controlled trials (RCTs) investigating the effects of MI alone or combined with DCI were reviewed. Nine RCTs involving 247 cases and 249 controls were included. Significant decreases in fasting insulin (SMD = -1.021 µU/mL, 95% CI: -1.791 to -0.251,

© 2017 The authors.

Keywords: d-chiro-inositol; inositol; insulin; myo-inositol; polycystic ovary syndrome

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