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Kitahata R, Nakajima S, Uchida H, et al. Self-rated cognitive functions following chemotherapy in patients with breast cancer: a 6-month prospective study. Neuropsychiatr Dis Treat. 2017;13:2489-2496doi: 10.2147/NDT.S141408.
Kitahata, R., Nakajima, S., Uchida, H., Hayashida, T., Takahashi, M., Nio, S., Hirano, J., Nagaoka, M., Suzuki, T., Jinno, H., Kitagawa, Y., & Mimura, M. (2017). Self-rated cognitive functions following chemotherapy in patients with breast cancer: a 6-month prospective study. Neuropsychiatric disease and treatment, 132489-2496. https://doi.org/10.2147/NDT.S141408
Kitahata, Ryosuke, et al. "Self-rated cognitive functions following chemotherapy in patients with breast cancer: a 6-month prospective study." Neuropsychiatric disease and treatment vol. 13 (2017): 2489-2496. doi: https://doi.org/10.2147/NDT.S141408
Kitahata R, Nakajima S, Uchida H, Hayashida T, Takahashi M, Nio S, Hirano J, Nagaoka M, Suzuki T, Jinno H, Kitagawa Y, Mimura M. Self-rated cognitive functions following chemotherapy in patients with breast cancer: a 6-month prospective study. Neuropsychiatr Dis Treat. 2017 Oct 03;13:2489-2496. doi: 10.2147/NDT.S141408. eCollection 2017. PMID: 29042777; PMCID: PMC5633301.
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Neuropsychiatr Dis Treat. 2017 Oct 03;13:2489-2496. doi: 10.2147/NDT.S141408. eCollection 2017.

Self-rated cognitive functions following chemotherapy in patients with breast cancer: a 6-month prospective study.

Neuropsychiatric disease and treatment

Ryosuke Kitahata, Shinichiro Nakajima, Hiroyuki Uchida, Tetsu Hayashida, Maiko Takahashi, Shintaro Nio, Jinichi Hirano, Maki Nagaoka, Takefumi Suzuki, Hiromitsu Jinno, Yuko Kitagawa, Masaru Mimura

Affiliations

  1. Psychopharmacology Research Program, Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan.
  2. Multimodal Imaging Group - Research Imaging Centre.
  3. Geriatric Mental Health Division, Centre for Addiction and Mental Health.
  4. Department of Psychiatry, University of Toronto, Toronto, Canada.
  5. Department of Surgery, School of Medicine, Keio University.
  6. Department of Surgery, School of Medicine, Teikyo University, Tokyo, Japan.

PMID: 29042777 PMCID: PMC5633301 DOI: 10.2147/NDT.S141408

Abstract

PURPOSE: The purpose of the study was to evaluate subjective (self-rated), family-rated, and objective (researcher-rated) cognitive functions in patients with breast cancer after chemotherapy.

METHOD: We conducted a prospective study to trace self-rated cognitive functions in 30 patients with breast cancer at the completion of chemotherapy (T0) and 6 months later (T1). Subjective cognitive functions were assessed with Cognitive Failures Questionnaire (CFQ), Dysexecutive Questionnaire (DEX-S), and Everyday Memory Checklist (EMC-S) for attention, executive function, and episodic memory, respectively. Their family members also completed DEX-I and EMC-I for executive function and episodic memory, respectively. We also examined objective cognitive functions. Self-rated cognitive functions were compared with the normative data. They were compared between T0 and T1. We calculated correlation coefficients between self-rated and other cognitive functions.

RESULTS: At T0, 6 (20.0%) and 2 (6.7%) participants showed higher DEX-S and EMC-S scores than the normative data, respectively, while no participant had abnormal CFQ scores. At T1, DEX-S and EMC-S scores were normalized in 3 (50.0%) and 2 (100.0%) participants, respectively. No participant showed increases in CFQ scores. No changes were found in objective cognitive functions from T0 to T1. DEX-S and DEX-I or EMC-S and EMC-I scores were correlated at both T0 and T1, which did not survive multiple corrections. There was no association between subjective and objective cognitive functions.

CONCLUSION: Impairments in subjective cognition may be transient after chemotherapy in patients with breast cancer. Furthermore, patients and their families appear to share similar prospects on their cognitive functions.

Keywords: breast cancer; chemotherapy; subjective cognitive functions

Conflict of interest statement

Disclosure Dr Ryosuke Kitahata has received Inokashira Hospital Research Grant within the past 3 years. Dr Shinichiro Nakajima has received fellowship grants from Canadian Institute of Health Research

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