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Fatima A, Farooq M, Abdullah U, et al. Genome-Wide Supported Risk Variants in . Psychiatry Investig. 2017;14(5):687-692doi: 10.4306/pi.2017.14.5.687.
Fatima, A., Farooq, M., Abdullah, U., Tariq, M., Mustafa, T., Iqbal, M., Tommerup, N., & Mahmood Baig, S. (2017). Genome-Wide Supported Risk Variants in . Psychiatry investigation, 14(5), 687-692. https://doi.org/10.4306/pi.2017.14.5.687
Fatima, Ambrin, et al. "Genome-Wide Supported Risk Variants in ." Psychiatry investigation vol. 14,5 (2017): 687-692. doi: https://doi.org/10.4306/pi.2017.14.5.687
Fatima A, Farooq M, Abdullah U, Tariq M, Mustafa T, Iqbal M, Tommerup N, Mahmood Baig S. Genome-Wide Supported Risk Variants in . Psychiatry Investig. 2017 Sep;14(5):687-692. doi: 10.4306/pi.2017.14.5.687. Epub 2017 Sep 11. PMID: 29042896; PMCID: PMC5639139.
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Psychiatry Investig. 2017 Sep;14(5):687-692. doi: 10.4306/pi.2017.14.5.687. Epub 2017 Sep 11.

Genome-Wide Supported Risk Variants in .

Psychiatry investigation

Ambrin Fatima, Muhammad Farooq, Uzma Abdullah, Muhammad Tariq, Tanveer Mustafa, Muhammad Iqbal, Niels Tommerup, Shahid Mahmood Baig

Affiliations

  1. Human Molecular Genetics Laboratory, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), PIEAS, Faisalabad, Pakistan.
  2. Wilhelm Johannsen Centre for Functional Genome Research, Institute of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
  3. PINUM Cancer Hospital, Faisalabad, Pakistan.

PMID: 29042896 PMCID: PMC5639139 DOI: 10.4306/pi.2017.14.5.687

Abstract

OBJECTIVE: Schizophrenia is a chronic neuropsychiatric disease afflicting around 1.1% of the population worldwide. Recently,

METHODS: Schizophrenia was diagnosed on the basis of the Diagnostic and Statistical Manual of Mental Disorders 4th ed (DSM-IV). Detailed clinical information, family history of all patients and healthy controls were collected. RFLP based case control association study was performed in a Pakistani cohort of 508 schizophrenia patients and 300 healthy control subjects. Alleles and genotype frequencies were calculated using SPSS.

RESULTS: A significant difference in the genotype and allele frequencies for rs4765905, rs1076560 and rs6465084 were found between the patients and controls (p=0.000).

CONCLUSION: This study provides substantial evidence supporting the role of

Keywords: CACNA1C; CSMD1; DRD2; GRM3; MIR137; Pakistan; Schizophrenia

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