Exp Ther Med. 2017 Oct;14(4):3908-3914. doi: 10.3892/etm.2017.4963. Epub 2017 Aug 18.
Effect of entecavir in the treatment of patients with hepatitis B virus-related compensated and decompensated cirrhosis.
Experimental and therapeutic medicine
Xiao-Dong Gai, Wei-Feng Wu
Affiliations
Affiliations
- The Second Department of Liver Medicine, The Second Affiliated Hospital of Southeast University, Nanjing, Jiangsu 210003, P.R. China.
PMID: 29043000
PMCID: PMC5639355 DOI: 10.3892/etm.2017.4963
Abstract
Chronic hepatitis B virus (CHB) infection is a burden on global healthcare and is associated with a higher risk of serious sequelae, including cirrhosis and hepatocellular carcinoma. The clinical application of entecavir as a treatment for CHB has produced positive outcomes, and so is an attractive form of pharmacological therapy. However, little data exists comparing the safety and efficacy of entecavir for the treatment of hepatitis B virus (HBV)-related compensated, and decompensated cirrhosis, respectively. The aim of the present study was to evaluate entecavir therapy as a treatment for patients with HBV-related compensated and decompensated cirrhosis. A retrospective analysis of 46 compensated patients (compensated group) and 51 decompensated cirrhotic patients (decompensated group) treated with entecavir was conducted. Baseline demographics, clinical outcomes, and adverse events during the treatment were compared. Treatment with entecavir for 96 weeks resulted in significant improvements in serum levels of HBV DNA (P=0.002), albumin (P=0.014), cholinesterase (CHE; P=0.001), HBV DNA negativity rate (P=0.004), Child-Turcotte-Pugh score (P=0.030), alanine aminotransferase normalized rate (P=0.039), and the degree of esophageal varices liver stiffness (P=0.002) in the two groups. However, statistical analysis revealed that the improvements were significantly higher in the compensated group compared with the decompensated group (P<0.05). The complement component (C)3 and C4 levels were also significantly increased in the compensated group compared with the decompensated group at weeks 24, 48 and 96 (P<0.05). In addition, the incidences of hepatocellular carcinoma, upper digestive tract hemorrhage and ascites were significantly higher in the decompensated group compared with the compensated group (P<0.05). In conclusion, treatment with 96-week entecavir therapy produced similar clinical outcomes in compensated and decompensated cirrhotic patients via inhibiting HBV-DNA viral load and recovering complement C3 and C4; however, entecavir exerts a better effect on patients with compensated cirrhosis, and so this therapy may improve the prognosis of such patients.
Keywords: cirrhosis; complement; efficacy; entecavir; hepatitis B virus
References
- Int J Clin Exp Med. 2015 Dec 15;8(12):22204-16 - PubMed
- Int J Clin Exp Pathol. 2014 Jun 15;7(7):4057-66 - PubMed
- Int J Clin Exp Pathol. 2015 Sep 01;8(9):11680-4 - PubMed
- Mediators Inflamm. 2015 ;2015 :535938 - PubMed
- Hepatol Int. 2016 Nov;10 (6):924-936 - PubMed
- Clin Gastroenterol Hepatol. 2011 Mar;9(3):274-6 - PubMed
- Zhonghua Gan Zang Bing Za Zhi. 2016 Jun;24(6):469-73 - PubMed
- Eur J Gastroenterol Hepatol. 2014 Apr;26(4):396-403 - PubMed
- J Clin Gastroenterol. 2011 May-Jun;45(5):449-55 - PubMed
- J Dig Dis. 2016 Aug;17 (8):538-546 - PubMed
- Hepatology. 2011 Jan;53(1):62-72 - PubMed
- Clin Exp Med. 2017 May;17 (2):233-241 - PubMed
- MMW Fortschr Med. 2011 Mar 31;153(13):22-3 - PubMed
- Aliment Pharmacol Ther. 2016 Aug;44(4):380-9 - PubMed
- Hepatol Res. 2017 Mar;47(3):E161-E168 - PubMed
- Int J Clin Exp Med. 2015 Nov 15;8(11):21062-70 - PubMed
- Hepat Mon. 2015 Aug 30;15(8):e29183 - PubMed
- Clin Gastroenterol Hepatol. 2012 May;10(5):527-34.e1-2 - PubMed
- World J Gastroenterol. 2015 Jul 7;21(25):7869-76 - PubMed
- World J Gastroenterol. 2015 Aug 28;21(32):9598-606 - PubMed
- J Viral Hepat. 2013 Apr;20 Suppl 1:58-64 - PubMed
- Med Clin North Am. 2009 Jul;93(4):787-99, vii - PubMed
- N Engl J Med. 2004 Oct 7;351(15):1521-31 - PubMed
- World J Surg. 2015 Nov;39(11):2764-70 - PubMed
- Medicine (Baltimore). 2016 Apr;95(16):e3372 - PubMed
- Eur J Gastroenterol Hepatol. 2013 Dec;25(12):1369-76 - PubMed
- Hum Pathol. 2009 Oct;40(10):1365-76 - PubMed
- World J Gastroenterol. 2013 Jun 14;19(22):3481-6 - PubMed
- Aliment Pharmacol Ther. 2014 Mar;39(5):532-9 - PubMed
- Korean J Gastroenterol. 2012 Mar;59(3):224-31 - PubMed
- Int J Clin Exp Pathol. 2015 Nov 01;8(11):15260-4 - PubMed
- Int J Clin Exp Med. 2015 Dec 15;8(12):22167-74 - PubMed
- Cell Physiol Biochem. 2016;40(1-2):370-378 - PubMed
- Biomed Res Int. 2016;2016:3524842 - PubMed
- Int J Mol Sci. 2016 May 25;17 (6): - PubMed
Publication Types