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Cheng X, Xie NC, Xu HL, et al. Biochemical aspirin resistance is associated with increased stroke severity and infarct volumes in ischemic stroke patients. Oncotarget. 2017;8(44):77086-77095doi: 10.18632/oncotarget.20356.
Cheng, X., Xie, N. C., Xu, H. L., Chen, C., & Lian, Y. J. (2017). Biochemical aspirin resistance is associated with increased stroke severity and infarct volumes in ischemic stroke patients. Oncotarget, 8(44), 77086-77095. https://doi.org/10.18632/oncotarget.20356
Cheng, Xuan, et al. "Biochemical aspirin resistance is associated with increased stroke severity and infarct volumes in ischemic stroke patients." Oncotarget vol. 8,44 (2017): 77086-77095. doi: https://doi.org/10.18632/oncotarget.20356
Cheng X, Xie NC, Xu HL, Chen C, Lian YJ. Biochemical aspirin resistance is associated with increased stroke severity and infarct volumes in ischemic stroke patients. Oncotarget. 2017 Aug 18;8(44):77086-77095. doi: 10.18632/oncotarget.20356. eCollection 2017 Sep 29. PMID: 29100372; PMCID: PMC5652766.
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Oncotarget. 2017 Aug 18;8(44):77086-77095. doi: 10.18632/oncotarget.20356. eCollection 2017 Sep 29.

Biochemical aspirin resistance is associated with increased stroke severity and infarct volumes in ischemic stroke patients.

Oncotarget

Xuan Cheng, Nan-Chang Xie, Hong-Liang Xu, Chen Chen, Ya-Jun Lian

Affiliations

  1. Department of Neurology, The first affiliated hospital of Zhengzhou University, Zhengzhou, Henan province, P.R. China.

PMID: 29100372 PMCID: PMC5652766 DOI: 10.18632/oncotarget.20356

Abstract

To explore the correlation of aspirin resistance (AR) with clinical stroke severity and infarct volume using diffusion-weighted imaging (DWI) in 224 Chinese ischemic stroke patients who were taking aspirin before stroke onset. In those patients, the median age was 64 years (IQR, 56-75 years), and males accounting for 54.9%(123)of the total subjects. Fifty of 224 enrolled patients (22.3%; 95% confidence interval (CI), 16.9% to 27.7%) showed AR. In the median regression model, significant increase was estimated in NIHSS score of 0.04 point for every 1-point increase in aspirin reaction units (ARU) (95% CI, 0.02 to 0.06;

Keywords: aspirin resistance; diffusion-weighted imaging; infarct volume; stroke severity

Conflict of interest statement

CONFLICTS OF INTEREST On behalf of all authors, the corresponding author states that there is no conflicts of interest.

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