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Cole J, Guiot MC, Gravel M, et al. Novel NAPRT specific antibody identifies small cell lung cancer and neuronal cancers as promising clinical indications for a NAMPT inhibitor/niacin co-administration strategy. Oncotarget. 2017;8(44):77846-77859doi: 10.18632/oncotarget.20840.
Cole, J., Guiot, M. C., Gravel, M., Bernier, C., Shore, G. C., & Roulston, A. (2017). Novel NAPRT specific antibody identifies small cell lung cancer and neuronal cancers as promising clinical indications for a NAMPT inhibitor/niacin co-administration strategy. Oncotarget, 8(44), 77846-77859. https://doi.org/10.18632/oncotarget.20840
Cole, Jonathan, et al. "Novel NAPRT specific antibody identifies small cell lung cancer and neuronal cancers as promising clinical indications for a NAMPT inhibitor/niacin co-administration strategy." Oncotarget vol. 8,44 (2017): 77846-77859. doi: https://doi.org/10.18632/oncotarget.20840
Cole J, Guiot MC, Gravel M, Bernier C, Shore GC, Roulston A. Novel NAPRT specific antibody identifies small cell lung cancer and neuronal cancers as promising clinical indications for a NAMPT inhibitor/niacin co-administration strategy. Oncotarget. 2017 Sep 12;8(44):77846-77859. doi: 10.18632/oncotarget.20840. eCollection 2017 Sep 29. PMID: 29100430; PMCID: PMC5652819.
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Oncotarget. 2017 Sep 12;8(44):77846-77859. doi: 10.18632/oncotarget.20840. eCollection 2017 Sep 29.

Novel NAPRT specific antibody identifies small cell lung cancer and neuronal cancers as promising clinical indications for a NAMPT inhibitor/niacin co-administration strategy.

Oncotarget

Jonathan Cole, Marie-Christine Guiot, Michel Gravel, Cynthia Bernier, Gordon C Shore, Anne Roulston

Affiliations

  1. Laboratory for Therapeutic Development, Rosalind and Morris Goodman Cancer Research Centre, and Department Biochemistry, McGill University, Montreal, QC, Canada.
  2. Department of Pathology, Montreal Neurological Hospital, Montreal, QC, Canada.

PMID: 29100430 PMCID: PMC5652819 DOI: 10.18632/oncotarget.20840

Abstract

Tumor cells are particularly dependent on NAD

Keywords: NAD+ biosynthesis; NAMPT; NAMPT inhibitor; NAPRT; biomarker

Conflict of interest statement

CONFLICTS OF INTEREST AR and GCS are former employees of Gemin X Pharmaceuticals Inc.; GCS was a shareholder in Gemin X Pharmaceuticals Inc. A provisional patent application for the 3C6D2 monoclonal a

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