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Kim J. Spermidine is protective against kidney ischemia and reperfusion injury through inhibiting DNA nitration and PARP1 activation. Anat Cell Biol. 2017;50(3):200-206doi: 10.5115/acb.2017.50.3.200.
Kim, J. (2017). Spermidine is protective against kidney ischemia and reperfusion injury through inhibiting DNA nitration and PARP1 activation. Anatomy & cell biology, 50(3), 200-206. https://doi.org/10.5115/acb.2017.50.3.200
Kim, Jinu. "Spermidine is protective against kidney ischemia and reperfusion injury through inhibiting DNA nitration and PARP1 activation." Anatomy & cell biology vol. 50,3 (2017): 200-206. doi: https://doi.org/10.5115/acb.2017.50.3.200
Kim J. Spermidine is protective against kidney ischemia and reperfusion injury through inhibiting DNA nitration and PARP1 activation. Anat Cell Biol. 2017 Sep;50(3):200-206. doi: 10.5115/acb.2017.50.3.200. Epub 2017 Sep 20. PMID: 29043098; PMCID: PMC5639174.
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Anat Cell Biol. 2017 Sep;50(3):200-206. doi: 10.5115/acb.2017.50.3.200. Epub 2017 Sep 20.

Spermidine is protective against kidney ischemia and reperfusion injury through inhibiting DNA nitration and PARP1 activation.

Anatomy & cell biology

Jinu Kim

Affiliations

  1. Department of Anatomy, Jeju National University School of Medicine, Jeju, Korea.
  2. Department of Biomedicine and Drug Development, Jeju National University, Jeju, Korea.

PMID: 29043098 PMCID: PMC5639174 DOI: 10.5115/acb.2017.50.3.200

Abstract

Kidney ischemia and reperfusion injury (IRI) is associated with a high mortality rate, which is attributed to tubular oxidative and nitrative stresses; however, an effective approach to limit IRI remains elusive. Spermidine, a naturally occurring polyamine, protects yeast cells against aging through the inhibition of oxidative stress and necrosis. In the present study, spermidine supplementation markedly attenuated histological damage and kidney dysfunction during IRI. In addition, exogenous spermidine potently inhibited poly(ADP-ribose) polymerase 1 (PARP1) activation and DNA nitrative/oxidative stress following IRI. Conversely, inhibition of ornithine decarboxylase (ODC) via siRNA transfection

Keywords: Ischemia and reperfusion injury; Nitration; Ornithine decarboxylase; Poly(ADP-ribose) polymerase 1; Spermidine

References

  1. Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G899-909 - PubMed
  2. Nat Cell Biol. 2009 Nov;11(11):1305-14 - PubMed
  3. Cell. 2012 May 25;149(5):1060-72 - PubMed
  4. Am J Physiol Renal Physiol. 2015 Feb 15;308(4):F298-308 - PubMed
  5. Am J Physiol Renal Physiol. 2009 Aug;297(2):F461-70 - PubMed
  6. Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13978-82 - PubMed
  7. Kidney Int. 2012 Jul;82(2):193-203 - PubMed
  8. Anat Cell Biol. 2015 Mar;48(1):66-74 - PubMed
  9. Eur J Pharmacol. 2007 May 21;562(3):236-46 - PubMed
  10. J Biol Chem. 2016 Jul 15;291(29):14904-12 - PubMed
  11. Transplantation. 2002 Jun 15;73(11):1693-700 - PubMed
  12. In Vitro Cell Dev Biol Anim. 2015 Jan;51(1):72-8 - PubMed
  13. Exp Neurol. 1991 Mar;111(3):349-55 - PubMed
  14. Brain Res. 2002 May 31;938(1-2):81-6 - PubMed
  15. Anat Cell Biol. 2016 Jun;49(2):79-87 - PubMed
  16. Physiol Rev. 2007 Jan;87(1):99-163 - PubMed
  17. Kidney Int. 2015 Feb;87(2):350-8 - PubMed
  18. J Biol Chem. 2006 Jul 21;281(29):20349-56 - PubMed
  19. Diabetes. 2005 Dec;54(12):3435-41 - PubMed
  20. Am J Physiol Renal Physiol. 2009 Mar;296(3):F622-33 - PubMed
  21. J Am Soc Nephrol. 2003 Aug;14(8):2199-210 - PubMed
  22. Anat Cell Biol. 2016 Sep;49(3):165-176 - PubMed
  23. Science. 2002 Jul 12;297(5579):259-63 - PubMed
  24. Curr Vasc Pharmacol. 2005 Jul;3(3):221-9 - PubMed
  25. Liver Transpl. 2016 Sep;22(9):1231-44 - PubMed
  26. Nat Med. 2016 Dec;22(12 ):1428-1438 - PubMed
  27. J Physiol Sci. 2015 Jan;65(1):105-11 - PubMed
  28. J Am Soc Nephrol. 2004 Jul;15(7):1844-52 - PubMed
  29. Nat Med. 2011 Nov 07;17(11):1391-401 - PubMed
  30. Eur J Neurosci. 1998 Jun;10(6):2046-55 - PubMed
  31. Am J Physiol Renal Physiol. 2003 Apr;284(4):F608-27 - PubMed
  32. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12024-9 - PubMed
  33. Physiol Res. 2016 Jun 20;65(2):333-40 - PubMed
  34. Eur J Neurosci. 1995 Sep 1;7(9):1840-9 - PubMed
  35. Pharmacol Res. 2005 Jul;52(1):44-59 - PubMed
  36. Am J Physiol Renal Physiol. 2011 Aug;301(2):F450-9 - PubMed
  37. Am J Physiol. 1999 Sep;277(3 Pt 2):F428-36 - PubMed
  38. Mol Cell. 2010 Jul 9;39(1):8-24 - PubMed
  39. Cell Biol Toxicol. 2017 May 24;:null - PubMed
  40. J Am Soc Nephrol. 2013 Feb;24(2):229-42 - PubMed

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