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Sewaralthahab K, Rennke H, Sewaralthahab S, et al. Potential association between membranous nephropathy and sargramostim therapy for pulmonary alveolar proteinosis. Clin Nephrol Case Stud. 2014;3:31-36doi: 10.5414/CNCS108420.
Sewaralthahab, K., Rennke, H., Sewaralthahab, S., Madias, N. E., & Jaber, B. L. (2015). Potential association between membranous nephropathy and sargramostim therapy for pulmonary alveolar proteinosis. Clinical nephrology. Case studies, 331-36. https://doi.org/10.5414/CNCS108420
Sewaralthahab, Kamal, et al. "Potential association between membranous nephropathy and sargramostim therapy for pulmonary alveolar proteinosis." Clinical nephrology. Case studies vol. 3 (2015): 31-36. doi: https://doi.org/10.5414/CNCS108420
Sewaralthahab K, Rennke H, Sewaralthahab S, Madias NE, Jaber BL. Potential association between membranous nephropathy and sargramostim therapy for pulmonary alveolar proteinosis. Clin Nephrol Case Stud. 2014 Dec 15;3:31-36. doi: 10.5414/CNCS108420. eCollection 2015. PMID: 29043131; PMCID: PMC5437997.
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Clin Nephrol Case Stud. 2014 Dec 15;3:31-36. doi: 10.5414/CNCS108420. eCollection 2015.

Potential association between membranous nephropathy and sargramostim therapy for pulmonary alveolar proteinosis.

Clinical nephrology. Case studies

Kamal Sewaralthahab, Helmut Rennke, Sarah Sewaralthahab, Nicolaos E Madias, Bertrand L Jaber

Affiliations

  1. Department of Medicine, Division of Nephrology, St. Elizabeth's Medical Center.
  2. Department of Medicine, Tufts University School of Medicine.
  3. Kidney Pathology Service, Department of Pathology, Brigham and Women's Hospital, Boston, MA, and.
  4. Department of Internal Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD, USA.

PMID: 29043131 PMCID: PMC5437997 DOI: 10.5414/CNCS108420

Abstract

We present the case of a 43-year-old woman with a diagnosis of pulmonary alveolar proteinosis, on chronic treatment with sargramostim, a recombinant granulocyte-macrophage colony-stimulating factor, who presented with the nephrotic syndrome secondary to biopsy-proven membranous nephropathy. We discuss potential underlying mechanisms, including speculated effects of sargramostim on mesangial cells and the kidney resident macrophages, and review the existing literature on the potential association between these two disorders.

Keywords: granulocyte-macrophage colony-stimulating factor; membranous nephropathy; pulmonary alveolar proteinosis; sargramostim

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