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Shiue Z, McNicholas B, Cormack F, et al. Antineutrophil cytoplasmic antibody mediated glomerulonephritis associated with levamisole-adulterated cocaine. Clin Nephrol Case Stud. 2014;3:37-41doi: 10.5414/CNCS108385.
Shiue, Z., McNicholas, B., Cormack, F., & Akilesh, S. (2015). Antineutrophil cytoplasmic antibody mediated glomerulonephritis associated with levamisole-adulterated cocaine. Clinical nephrology. Case studies, 337-41. https://doi.org/10.5414/CNCS108385
Shiue, Zita, et al. "Antineutrophil cytoplasmic antibody mediated glomerulonephritis associated with levamisole-adulterated cocaine." Clinical nephrology. Case studies vol. 3 (2015): 37-41. doi: https://doi.org/10.5414/CNCS108385
Shiue Z, McNicholas B, Cormack F, Akilesh S. Antineutrophil cytoplasmic antibody mediated glomerulonephritis associated with levamisole-adulterated cocaine. Clin Nephrol Case Stud. 2014 Dec 15;3:37-41. doi: 10.5414/CNCS108385. eCollection 2015. PMID: 29043132; PMCID: PMC5437994.
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Clin Nephrol Case Stud. 2014 Dec 15;3:37-41. doi: 10.5414/CNCS108385. eCollection 2015.

Antineutrophil cytoplasmic antibody mediated glomerulonephritis associated with levamisole-adulterated cocaine.

Clinical nephrology. Case studies

Zita Shiue, Bairbre McNicholas, Fionnuala Cormack, Shreeram Akilesh

Affiliations

  1. Division of Nephrology and.

PMID: 29043132 PMCID: PMC5437994 DOI: 10.5414/CNCS108385

Abstract

Levamisole-adulterated cocaine has increased in prevalence over the last decade and is known to be associated with antineutrophil cytoplasmic antibodies (ANCA). Dermatologic manifestations of levamisole exposure, including cutaneous vasculitis, are widely appreciated; less is known about its effects on the kidney. We report two cases of patients with a history of cocaine abuse and levamisole-induced cutaneous vasculitis, who developed acute kidney injury in the setting of elevated ANCA titers. Renal biopsies of both revealed pauci-immune complex glomerulonephritis with diffuse crescentic disease. These cases demonstrate a rare but serious complication of long-term cocaine use.

Keywords: ANCA; cocaine; glomerulonephritis; levamisole

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