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Mbow M, Santos NSS, Camara M, et al. HIV and Tuberculosis co-infection impacts T-cell activation markers but not the numbers subset of regulatory T-cells in HIV-1 infected patients. Afr J Lab Med. 2013;2(1):76doi: 10.4102/ajlm.v2i1.76.
Mbow, M., Santos, N. S. S., Camara, M., Ba, A., Niang, A., Daneau, G., Wade, D., Diallo, A. A., Toupane, M., Diakhaté, M., Lèye, N., Diaw, P. A., Mboup, S., Kestens, L., & Dieye, T. N. (2013). HIV and Tuberculosis co-infection impacts T-cell activation markers but not the numbers subset of regulatory T-cells in HIV-1 infected patients. African journal of laboratory medicine, 2(1), 76. https://doi.org/10.4102/ajlm.v2i1.76
Mbow, Moustapha, et al. "HIV and Tuberculosis co-infection impacts T-cell activation markers but not the numbers subset of regulatory T-cells in HIV-1 infected patients." African journal of laboratory medicine vol. 2,1 (2013): 76. doi: https://doi.org/10.4102/ajlm.v2i1.76
Mbow M, Santos NSS, Camara M, Ba A, Niang A, Daneau G, Wade D, Diallo AA, Toupane M, Diakhaté M, Lèye N, Diaw PA, Mboup S, Kestens L, Dieye TN. HIV and Tuberculosis co-infection impacts T-cell activation markers but not the numbers subset of regulatory T-cells in HIV-1 infected patients. Afr J Lab Med. 2013 Sep 02;2(1):76. doi: 10.4102/ajlm.v2i1.76. eCollection 2013. PMID: 29043167; PMCID: PMC5637782.
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Afr J Lab Med. 2013 Sep 02;2(1):76. doi: 10.4102/ajlm.v2i1.76. eCollection 2013.

HIV and Tuberculosis co-infection impacts T-cell activation markers but not the numbers subset of regulatory T-cells in HIV-1 infected patients.

African journal of laboratory medicine

Moustapha Mbow, Ndèye S S Santos, Makhtar Camara, Awa Ba, Aliou Niang, Géraldine Daneau, Djibril Wade, Abdou A Diallo, Maxim Toupane, Maïmouna Diakhaté, Nafissatou Lèye, Papa A Diaw, Souleymane Mboup, Luc Kestens, Tandakha N Dieye

Affiliations

  1. Laboratory of Bacteriology and Virology, Aristide Le Dantec University Hospital, Dakar, Sénégal.
  2. Institute of Tropical Medicine, Unit of Immunology, Department of Biomedical Sciences, Antwerp, Belgium.
  3. Department of Pneumo-phthisiology, Fann University Hospital, Dakar, Sénégal.

PMID: 29043167 PMCID: PMC5637782 DOI: 10.4102/ajlm.v2i1.76

Abstract

BACKGROUND: Tuberculosis (TB) has been shown to accelerate the clinical course of HIV infection, but the mechanisms by which this occurs are not well understood. Regulatory T-cells (Tregs) are known to dampen hyperactivation of the immune cells, but it remains unclear whether hyperactivation of T-cells in HIV infection is associated with a decrease of Tregs and what the effect

OBJECTIVES: In this study, we aim to evaluate whether active TB is associated with the increased expression of T-cell activation markers and reduced number of Treg cells in HIV-1-infected patients.

METHODS: This study was conducted on 69 subjects consisting of 20 HIV-infected patients, 20 HIV and MTB co-infected patients, 19 MTB-infected patients and 10 uninfected control subjects negative for both MTB and HIV. The frequencies of T-cell activation markers (CD38 and HLA-DR) and Treg cells (CD4

RESULTS: Significantly higher expression of CD38 and HLA-DR on CD4

CONCLUSION: These results suggest that TB enhances the expression of peripheral T-cell activation markers during HIV infection, whilst having no impact on the percentages of Treg cells.

Conflict of interest statement

The authors declare that they have no financial or personal relationship(s) which may have inappropriately influenced them in writing this article.

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