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Ignatov AV, Bondarenko KA, Makarova AV. Non-bulky Lesions in Human DNA: the Ways of Formation, Repair, and Replication. Acta Naturae. 2017;9(3):12-26
Ignatov, A. V., Bondarenko, K. A., & Makarova, A. V. (2017). Non-bulky Lesions in Human DNA: the Ways of Formation, Repair, and Replication. Acta naturae, 9(3), 12-26.
Ignatov, A V, et al. "Non-bulky Lesions in Human DNA: the Ways of Formation, Repair, and Replication." Acta naturae vol. 9,3 (2017): 12-26.
Ignatov AV, Bondarenko KA, Makarova AV. Non-bulky Lesions in Human DNA: the Ways of Formation, Repair, and Replication. Acta Naturae. 2017 Jul-Sep;9(3):12-26. PMID: 29104772; PMCID: PMC5662270.
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Acta Naturae. 2017 Jul-Sep;9(3):12-26.

Non-bulky Lesions in Human DNA: the Ways of Formation, Repair, and Replication.

Acta naturae

A V Ignatov, K A Bondarenko, A V Makarova

Affiliations

  1. Institute of Molecular Genetics of Russian Academy of Sciences, Kurchatov sq. 2, Moscow, 123182 , Russia.
  2. Department of Molecular Biology, Faculty of Biology, Moscow State University, Leninskie Gory 1, bldg. 12, Moscow, 119991, Russia.

PMID: 29104772 PMCID: PMC5662270

Abstract

DNA damage is a major cause of replication interruption, mutations, and cell death. DNA damage is removed by several types of repair processes. The involvement of specialized DNA polymerases in replication provides an important mechanism that helps tolerate persistent DNA damage. Specialized DNA polymerases incorporate nucleotides opposite lesions with high efficiency but demonstrate low accuracy of DNA synthesis. In this review, we summarize the types and mechanisms of formation and repair of non-bulky DNA lesions, and we provide an overview of the role of specialized DNA polymerases in translesion DNA synthesis.

Keywords: DNA damage; DNA repair; DNA translesion synthesis

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