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mSphere. 2017 Nov 01;2(6). doi: 10.1128/mSphere.00398-17. eCollection 2017.

Modeling Group B .

mSphere

Brandon J Kim, Olivia B Bee, Maura A McDonagh, Matthew J Stebbins, Sean P Palecek, Kelly S Doran, Eric V Shusta

Affiliations

  1. Department of Chemical and Biological Engineering, University of Wisconsin, Madison, Wisconsin, USA.
  2. Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.

PMID: 29104935 PMCID: PMC5663983 DOI: 10.1128/mSphere.00398-17

Abstract

Bacterial meningitis is a serious infection of the central nervous system (CNS) that occurs after bacteria interact with and penetrate the blood-brain barrier (BBB). The BBB is comprised of highly specialized brain microvascular endothelial cells (BMECs) that function to separate the circulation from the CNS and act as a formidable barrier for toxins and pathogens. Certain bacteria, such as

Keywords: blood-brain barrier; group B Streptococcus; stem cells

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